PGAM5

PGAM5, full name Phosphoglycerate mutase family member 5, is a mitochondrial membrane-associated serine/threonine phosphatase. Common aliases include PGAM5L. It modulates mitochondrial dynamics (fusion and fission) and key cell death pathways: it dephosphorylates RIPK3 and MLKL to drive necroptosis, and interacts with Parkin to regulate mitophagy.
Dysregulated PGAM5 is linked to neurodegenerative diseases like Parkinson’s, certain cancers (promoting tumor progression), and inflammatory conditions. Current drug development focuses on small-molecule inhibitors targeting its phosphatase activity to suppress necroptosis, with preclinical candidates under evaluation but no approved therapies yet.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

PGAM5 Antibody (CSB-PA839338LA01HU)

Validated Data

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA839338LA01HU at dilution of 1: 100

Immunofluorescent analysis of Hela cells using CSB-PA839338LA01HU at dilution of 1: 100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

The following PGAM5 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

PGAM5 Antibodies

PGAM5 Proteins

PGAM5 Antibodies

PGAM5 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA839338LA01HU	PGAM5 Antibody	Human	ELISA, IHC, IF
CSB-PA839338LB01HU	PGAM5 Antibody, HRP conjugated	Human	ELISA
CSB-PA839338LC01HU	PGAM5 Antibody, FITC conjugated	Human
CSB-PA839338LD01HU	PGAM5 Antibody, Biotin conjugated	Human	ELISA

PGAM5 Antibodies for Drosophila yakuba (Fruit fly)

Code	Product Name	Species Reactivity	Application
CSB-PA457718XA01DMR	Pgam5 Antibody	Drosophila yakuba (Fruit fly)	ELISA, WB (ensure identification of antigen)

PGAM5 Antibodies for Drosophila erecta (Fruit fly)

Code	Product Name	Species Reactivity	Application
CSB-PA455403XA01DLK	Pgam5 Antibody	Drosophila erecta (Fruit fly)	ELISA, WB (ensure identification of antigen)

PGAM5 Antibodies for Drosophila sechellia (Fruit fly)

Code	Product Name	Species Reactivity	Application
CSB-PA463506XA01DMG	Pgam5 Antibody	Drosophila sechellia (Fruit fly)	ELISA, WB (ensure identification of antigen)

PGAM5 Antibodies for Drosophila simulans (Fruit fly)

Code	Product Name	Species Reactivity	Application
CSB-PA457728XA01DMJ	Pgam5 Antibody	Drosophila simulans (Fruit fly)	ELISA, WB (ensure identification of antigen)

PGAM5 Antibodies for Drosophila ananassae (Fruit fly)

Code	Product Name	Species Reactivity	Application
CSB-PA457291XA01DKY	Pgam5 Antibody	Drosophila ananassae (Fruit fly)	ELISA, WB (ensure identification of antigen)

PGAM5 Antibodies for Drosophila melanogaster (Fruit fly)

Code	Product Name	Species Reactivity	Application
CSB-PA524299XA01DLU	Pgam5 Antibody	Drosophila melanogaster (Fruit fly)	ELISA, WB (ensure identification of antigen)

PGAM5 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)

Code	Product Name	Species Reactivity	Application
CSB-PA709473XA01DIL	pgam5 Antibody	Danio rerio (Zebrafish) (Brachydanio rerio)	ELISA, WB (ensure identification of antigen)

PGAM5 Proteins

PGAM5 Proteins for Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi)

Code	Product Name	Source
CSB-YP451856DLL CSB-EP451856DLL CSB-BP451856DLL CSB-MP451856DLL CSB-EP451856DLL-B	Recombinant Drosophila grimshawi Serine/threonine-protein phosphatase Pgam5, mitochondrial (Pgam5)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PGAM5 Proteins for Drosophila mojavensis (Fruit fly)

Code	Product Name	Source
CSB-YP453812DLY CSB-EP453812DLY CSB-BP453812DLY CSB-MP453812DLY CSB-EP453812DLY-B	Recombinant Drosophila mojavensis Serine/threonine-protein phosphatase Pgam5, mitochondrial (Pgam5)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PGAM5 Proteins for Drosophila erecta (Fruit fly)

Code	Product Name	Source
CSB-YP455403DLK CSB-EP455403DLK CSB-BP455403DLK CSB-MP455403DLK CSB-EP455403DLK-B	Recombinant Drosophila erecta Serine/threonine-protein phosphatase Pgam5, mitochondrial (Pgam5), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PGAM5 Proteins for Drosophila ananassae (Fruit fly)

Code	Product Name	Source
CSB-YP457291DKY CSB-EP457291DKY CSB-BP457291DKY CSB-MP457291DKY CSB-EP457291DKY-B	Recombinant Drosophila ananassae Serine/threonine-protein phosphatase Pgam5, mitochondrial (Pgam5), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PGAM5 Proteins for Drosophila virilis (Fruit fly)

Code	Product Name	Source
CSB-YP457693DMP CSB-EP457693DMP CSB-BP457693DMP CSB-MP457693DMP CSB-EP457693DMP-B	Recombinant Drosophila virilis Serine/threonine-protein phosphatase Pgam5, mitochondrial (Pgam5), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PGAM5 Proteins for Drosophila yakuba (Fruit fly)

Code	Product Name	Source
CSB-YP457718DMR CSB-EP457718DMR CSB-BP457718DMR CSB-MP457718DMR CSB-EP457718DMR-B	Recombinant Drosophila yakuba Serine/threonine-protein phosphatase Pgam5, mitochondrial (Pgam5)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PGAM5 Proteins for Drosophila simulans (Fruit fly)

Code	Product Name	Source
CSB-YP457728DMJ CSB-EP457728DMJ CSB-BP457728DMJ CSB-MP457728DMJ CSB-EP457728DMJ-B	Recombinant Drosophila simulans Serine/threonine-protein phosphatase Pgam5, mitochondrial (Pgam5), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PGAM5 Proteins for Drosophila persimilis (Fruit fly)

Code	Product Name	Source
CSB-YP463491DMB CSB-EP463491DMB CSB-BP463491DMB CSB-MP463491DMB CSB-EP463491DMB-B	Recombinant Drosophila persimilis Serine/threonine-protein phosphatase Pgam5, mitochondrial (Pgam5), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PGAM5 Proteins for Drosophila sechellia (Fruit fly)

Code	Product Name	Source
CSB-YP463506DMG CSB-EP463506DMG CSB-BP463506DMG CSB-MP463506DMG CSB-EP463506DMG-B	Recombinant Drosophila sechellia Serine/threonine-protein phosphatase Pgam5, mitochondrial (Pgam5), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PGAM5 Proteins for Drosophila willistoni (Fruit fly)

Code	Product Name	Source
CSB-YP465488DMQ CSB-EP465488DMQ CSB-BP465488DMQ CSB-MP465488DMQ CSB-EP465488DMQ-B	Recombinant Drosophila willistoni Serine/threonine-protein phosphatase Pgam5, mitochondrial (Pgam5), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PGAM5 Proteins for Drosophila melanogaster (Fruit fly)

Code	Product Name	Source
CSB-YP524299DLU CSB-EP524299DLU CSB-BP524299DLU CSB-MP524299DLU CSB-EP524299DLU-B	Recombinant Drosophila melanogaster Serine/threonine-protein phosphatase Pgam5, mitochondrial (Pgam5), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PGAM5 Proteins for Drosophila pseudoobscura pseudoobscura (Fruit fly)

Code	Product Name	Source
CSB-YP645873DME CSB-EP645873DME CSB-BP645873DME CSB-MP645873DME CSB-EP645873DME-B	Recombinant Drosophila pseudoobscura pseudoobscura Serine/threonine-protein phosphatase Pgam5, mitochondrial (Pgam5), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PGAM5 Proteins for Xenopus laevis (African clawed frog)

Code	Product Name	Source
CSB-YP685921XBE CSB-EP685921XBE CSB-BP685921XBE CSB-MP685921XBE CSB-EP685921XBE-B	Recombinant Xenopus laevis Serine/threonine-protein phosphatase PGAM5, mitochondrial (pgam5), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PGAM5 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP687927RA CSB-EP687927RA CSB-BP687927RA CSB-MP687927RA CSB-EP687927RA-B	Recombinant Rat Serine/threonine-protein phosphatase PGAM5, mitochondrial (Pgam5), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PGAM5 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

Code	Product Name	Source
CSB-YP709473DIL CSB-EP709473DIL CSB-BP709473DIL CSB-MP709473DIL CSB-EP709473DIL-B	Recombinant Danio rerio Serine/threonine-protein phosphatase PGAM5, mitochondrial (pgam5), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PGAM5 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Code	Product Name	Source
CSB-YP750175XBF CSB-EP750175XBF CSB-BP750175XBF CSB-MP750175XBF CSB-EP750175XBF-B	Recombinant Xenopus tropicalis Serine/threonine-protein phosphatase PGAM5, mitochondrial (pgam5), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PGAM5 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP805980MO CSB-EP805980MO CSB-BP805980MO CSB-MP805980MO CSB-EP805980MO-B	Recombinant Mouse Serine/threonine-protein phosphatase PGAM5, mitochondrial (Pgam5), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PGAM5 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-MP839338HU CSB-EP839338HU-B	Recombinant Human Serine/threonine-protein phosphatase PGAM5, mitochondrial (PGAM5), partial	Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP839338HU	Recombinant Human Serine/threonine-protein phosphatase PGAM5,mitochondrial (PGAM5), partial	E.coli
CSB-EP839338HUc7	Recombinant Human Serine/threonine-protein phosphatase PGAM5,mitochondrial (PGAM5), partial	E.coli
CSB-YP839338HU	Recombinant Human Serine/threonine-protein phosphatase PGAM5, mitochondrial (PGAM5), partial	Yeast
CSB-BP839338HU	Recombinant Human Serine/threonine-protein phosphatase PGAM5, mitochondrial (PGAM5), partial	Baculovirus
CSB-CF839338HU(A4)(M)	Recombinant Human Serine/threonine-protein phosphatase PGAM5,mitochondrial (PGAM5) (G166A,V167A,K169A)	in vitro E.coli expression system

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PGAM5

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