PHB2

PHB2, known as prohibitin 2, is also commonly referred to as BAP32. This protein is a highly conserved and ubiquitously expressed protein. It localizes mainly to the inner mitochondrial membrane and can also be found in the nucleus and other sub - cellular compartments. PHB2 functions by interacting with multiple proteins to regulate mitochondrial morphology, dynamics, and function. It is involved in the mTOR and MAPK signaling pathways, which are crucial for cell growth, proliferation, and survival.
Aberrant expression of PHB2 has been associated with various diseases such as cancer, neurodegenerative disorders, and cardiovascular diseases. Given its important role in these conditions, PHB2 has emerged as a potential drug target. Some small - molecule inhibitors and peptide - based agents are under development, aiming to modulate its activity for therapeutic benefits.