E3 SUMO-protein ligase PIAS1 is a protein in humans that is encoded by PIAS1 gene. Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling.
The following PIAS1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
PIAS1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA017957ESR1HU | PIAS1 Antibody |
Human | ELISA, IHC |
CSB-PA158229 | PIAS1 Antibody |
Human,Mouse | ELISA,WB,IHC |
CSB-PA003776 | PIAS1 Antibody |
Human,Mouse | WB, IHC, ELISA |
CSB-PA037444 | PIAS1 Antibody |
Human | ELISA,WB |
PIAS1 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP017957MO1 CSB-EP017957MO1 CSB-BP017957MO1 CSB-MP017957MO1 CSB-EP017957MO1-B |
Recombinant Mouse E3 SUMO-protein ligase PIAS1 (Pias1), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PIAS1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP017957HU CSB-EP017957HU CSB-BP017957HU CSB-MP017957HU CSB-EP017957HU-B |
Recombinant Human E3 SUMO-protein ligase PIAS1 (PIAS1) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |