PLXNB1

PLXNB1 (Plexin B1) is a cell surface receptor protein belonging to the protein glycan receptor family, and it plays a pivotal role in various biological processes. Typically expressed in the nervous system, it consists of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain comprises multiple repetitive structural units responsible for interactions with its ligands and other molecules. The intracellular domain includes several functional domains involved in signal transduction and intracellular signaling pathways.

The functions of PLXNB1 encompass the development, guidance, and regulation of the nervous system, as well as other biological processes. As a cell surface receptor, it primarily participates in interactions between cells and between cells and the external environment. PLXNB1 interacts with its ligands, Class 3 Semaphorins, which are steroid hormone receptor core transcription factors, and contributes to neuronal guidance and synapse formation.

In-depth research on PLXNB1 contributes to a better understanding of nervous system development and function, potentially offering therapeutic strategies for neurological disorders. Moreover, it may have broader applications in various fields.

Popular Product

Recombinant Human Plexin-B1(PLXNB1),partial (Active)CSB-MP018222HU2k6

Validated Data

SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ELISA

Activity: Measured by its binding ability in a functional ELISA. Immobilized human SEMA4D (CSB-MP835707HUd9) at 5 μg/ml can bind human PLXNB1, the EC₅₀ is 0.8179-1.357 μg/ml.