PTK6

PTK6, also known as protein tyrosine kinase 6, is also commonly referred to as BRK (breast tumor kinase). It is a non - receptor tyrosine kinase. PTK6 exerts its function by phosphorylating various substrate proteins, thereby regulating cell growth, survival, and migration. It is involved in multiple signaling pathways such as the EGFR and ER signaling pathways.
Aberrant activation of PTK6 is associated with several diseases, especially breast, ovarian, and colon cancers. In drug development, targeting PTK6 has emerged as a promising strategy. Some small - molecule inhibitors are under pre - clinical and clinical investigations to assess their efficacy in treating related cancers, aiming to block its kinase activity and thus inhibit tumor progression.