RAB5A

RAB5A, also known as Ras-related protein Rab-5A, is a member of the Rab GTPase family. It is commonly referred to as Rab5. This protein plays a crucial role in the early endocytic pathway, regulating vesicle trafficking and fusion. It acts as a molecular switch, cycling between an active GTP - bound and an inactive GDP - bound state. RAB5A is involved in the PI3K - Akt signaling pathway.
Alterations in RAB5A have been associated with various diseases, including cancer and neurodegenerative disorders. In cancer, abnormal RAB5A activity can promote cell invasion and metastasis. Regarding drug development, research is underway to target RAB5A - related pathways to develop novel therapies, but significant progress is yet to be achieved.