REN, or renin, is produced by the proximal glomerular cells of the kidney. Renin is a protein hydrolyzing enzyme that mainly acts on angiotensinogen in plasma to produce inactive angiotensin I. Angiotensin I is further converted to active angiotensin II by angiotensin-converting enzyme, which causes vasoconstriction of small arteries and promotes the synthesis and secretion of aldosterone from the adrenal cortex, thus elevating blood pressure.
The renin-angiotensin system (RAS) plays an important role in the regulation of blood pressure, fluid and electrolyte homeostasis, and is essential for the maintenance of normal physiologic function. The release of renin is a critical determinant of plasma angiotensin concentration and has important implications for the bioactivity of angiotensin II and III.
REN Antibody (CSB-PA12069A0Rb)
Validated Data
Western Blot
Positive WB detected in: Mouse heart tissue, Mouse spleen tissue, Mouse lung tissue, Mouse stomach tissue
All lanes: REN antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 46, 45 kDa
Observed band size: 46, 29 kDa
Immunofluorescent analysis of HepG2 cells using CSB-PA12069A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Human renin (REN) ELISA Kit (CSB-E08701h)
Validated Data
Code: CSB-E08701h
Size: 96T,5×96T,10×96T
Sensitivity: 3.9 mIU/mL
Detection Range: 15.6 mIU/mL-1000 mIU/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
The following REN reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
REN Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA019561GA01HU | REN Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
CSB-PA040200 | REN Antibody | Human | WB, IHC, ELISA |
CSB-PA284388 | REN Antibody | Human | ELISA,IHC |
CSB-PA12069A0Rb | REN Antibody | Human, Mouse | ELISA, WB, IF |
CSB-PA12069B0Rb | REN Antibody, HRP conjugated | Human | ELISA |
CSB-PA12069C0Rb | REN Antibody, FITC conjugated | Human | |
CSB-PA12069D0Rb | REN Antibody, Biotin conjugated | Human | ELISA |
REN Antibodies for Escherichia phage lambda (Bacteriophage lambda)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA366041XA01FSF | ren Antibody | Escherichia phage lambda (Bacteriophage lambda) | ELISA, WB (ensure identification of antigen) |
REN Proteins for Ovis aries (Sheep)
Code | Product Name | Source |
---|---|---|
CSB-YP019561SH CSB-EP019561SH CSB-BP019561SH CSB-MP019561SH CSB-EP019561SH-B |
Recombinant Sheep Renin (REN) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
REN Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP019561HU CSB-EP019561HU CSB-BP019561HU CSB-MP019561HU CSB-EP019561HU-B |
Recombinant Human Renin (REN) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
REN Proteins for Escherichia phage lambda (Bacteriophage lambda)
Code | Product Name | Source |
---|---|---|
CSB-YP366041ECW CSB-EP366041ECW CSB-BP366041ECW CSB-MP366041ECW CSB-EP366041ECW-B |
Recombinant Enterobacteria phage lambda Protein ren (ren) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
REN Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Code | Product Name | Source |
---|---|---|
CSB-YP715703MOV CSB-BP715703MOV CSB-MP715703MOV CSB-EP715703MOV-B |
Recombinant Macaca fascicularis Renin (REN) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
REN Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
Code | Product Name | Source |
---|---|---|
CSB-YP721926DO CSB-EP721926DO CSB-BP721926DO CSB-MP721926DO CSB-EP721926DO-B |
Recombinant Dog Renin (REN) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
REN Proteins for Macaca mulatta (Rhesus macaque)
Code | Product Name | Source |
---|---|---|
CSB-YP735332MOW CSB-EP735332MOW CSB-BP735332MOW CSB-MP735332MOW CSB-EP735332MOW-B |
Recombinant Macaca mulatta Renin (REN) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
REN Proteins for Callithrix jacchus (White-tufted-ear marmoset)
Code | Product Name | Source |
---|---|---|
CSB-YP883286CYL CSB-EP883286CYL CSB-BP883286CYL CSB-MP883286CYL CSB-EP883286CYL-B |
Recombinant Callithrix jacchus Renin (REN) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
REN ELISA Kit for Canis lupus familiaris (Dog) (Canis familiaris)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E08704c | Dog Renin ELISA Kit | serum, plasma, tissue homogenates | 15.6 pg/mL |
REN ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E08701h | Human renin (REN) ELISA Kit | serum, plasma, tissue homogenates | 3.9 mIU/mL |