RIPK3

RIPK3, also known as receptor-interacting serine/threonine-protein kinase 3, is a crucial component in the regulation of programmed cell death pathways. It is commonly referred to as RIP3. RIPK3 functions through phosphorylation, which activates MLKL to induce necroptosis, a regulated form of necrosis. This protein is involved in the TNF signaling pathway and plays a vital role in inflammation.
Dysregulation of RIPK3 has been linked to various diseases, including neurodegenerative diseases, inflammatory bowel disease, and certain types of cancer. In drug development, inhibitors targeting RIPK3 are being explored as potential treatments for these diseases. Some inhibitors have shown promising results in pre - clinical studies, aiming to modulate cell death and inflammation.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

RIPK3 Antibody (CSB-PA897497ESR1HU)

Validated Data

Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA897497ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA897497ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA897497ESR1HU at dilution of 1:100

Human Receptor-interacting serine/threonine-protein kinase 3(RIPK3) ELISA kit (CSB-EL019737HU)

Validated Data

Code: CSB-EL019737HU

Size: 96T,5×96T,10×96T

Sensitivity: 0.039 ng/ml

Detection Range: 0.156 ng/ml-10 ng/ml

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following RIPK3 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

RIPK3 Antibodies

RIPK3 Proteins

RIPK3 ELISA Kits

RIPK3 Antibodies

RIPK3 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA019737GA01HU	RIPK3 Antibody	Human	ELISA,WB
CSB-PA897497ESR1HU	RIPK3 Antibody	Human	ELISA, IHC
CSB-PA897497LA01HU	RIPK3 Antibody	Human	ELISA, WB, IHC, IF
CSB-PA897497LD01HU	RIPK3 Antibody, Biotin conjugated	Human	ELISA
CSB-PA897497LC01HU	RIPK3 Antibody, FITC conjugated	Human
CSB-PA897497LB01HU	RIPK3 Antibody, HRP conjugated	Human	ELISA

RIPK3 Proteins

RIPK3 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP886403MO	Recombinant Mouse Receptor-interacting serine/threonine-protein kinase 3 (Ripk3)	Yeast
CSB-EP886403MO CSB-BP886403MO CSB-MP886403MO CSB-EP886403MO-B	Recombinant Mouse Receptor-interacting serine/threonine-protein kinase 3 (Ripk3)	E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

RIPK3 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP897497HU	Recombinant Human Receptor-interacting serine/threonine-protein kinase 3 (RIPK3)	Yeast
CSB-EP897497HU	Recombinant Human Receptor-interacting serine/threonine-protein kinase 3 (RIPK3)	E.coli
CSB-BP897497HU	Recombinant Human Receptor-interacting serine/threonine-protein kinase 3 (RIPK3)	Baculovirus
CSB-MP897497HU CSB-EP897497HU-B	Recombinant Human Receptor-interacting serine/threonine-protein kinase 3 (RIPK3)	Mammalian cell In Vivo Biotinylation in E.coli