ROPN1

ROPN1 is also referred to as CT91 and ODF6. This protein is primarily located in the fibrous sheath at the tail of sperm, where it plays a crucial role in regulating sperm motility through interactions with proteins like rhophilin. ROPN1 is not only essential for reproductive function but also serves as a significant cancer-testicular antigen, with notable expression in specific tumors such as hematological malignancies and triple-negative breast cancer. Its distinct expression pattern positions ROPN1 as a promising target for cancer treatment, highlighting its potential clinical application. Investigating the function and regulatory mechanisms of ROPN1 will enhance our understanding of reproductive physiology and tumor pathology, offering new insights for the diagnosis and treatment of related diseases.