RPGR retinal pigmentation GTPase regulator is an important protein consisting of multiple isoforms, which are generated through alternative splicing and contain the RLD and CAAX domains. It mainly functions in the connecting cilia of retinal photoreceptor cells. RPGR is involved in the biosynthesis and maintenance of cilia and is crucial for the function of retinal photoreceptor cells. In addition, RPGR acts as a guanine nucleotide exchange factor for the small GTPase RAB37, regulating the activity of RAB37 and affecting the autophagy process. It is also associated with signaling pathways such as Akt, Erk1/2, focal adhesion kinase, and Src, which have important effects on the regulation of actin stress fibers and cell cycle progression in cells. The signaling pathways involved in RPGR include the cilia signaling pathway, the autophagy signaling pathway, and the cytoskeleton regulation signaling pathway. Mutations in RPGR are associated with various genetic retinal diseases, making it an important target for research and treatment of related retinal diseases.
Recombinant Human X-linked retinitis pigmentosa GTPase regulator (RPGR), partial (CSB-MP838814HU)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
The following RPGR reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
RPGR Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
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CSB-PA020099GA01HU | RPGR Antibody | Human,Mouse,Rat | ELISA,WB,IF |
CSB-PA838814LA01HU | RPGR Antibody | Human | ELISA, WB, IHC, IF |
CSB-PA838814LC01HU | RPGR Antibody, FITC conjugated | Human | |
CSB-PA838814LD01HU | RPGR Antibody, Biotin conjugated | Human | ELISA |
CSB-PA838814LB01HU | RPGR Antibody, HRP conjugated | Human | ELISA |
RPGR Proteins for Homo sapiens (Human)
Code | Product Name | Source |
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CSB-YP838814HU CSB-EP838814HU CSB-BP838814HU CSB-EP838814HU-B |
Recombinant Human X-linked retinitis pigmentosa GTPase regulator (RPGR), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
CSB-MP838814HU | Recombinant Human X-linked retinitis pigmentosa GTPase regulator (RPGR), partial | Mammalian cell |