RPL6

RPL6 encodes ribosomal protein L6, a component of the 60S large ribosomal subunit. It plays a crucial role in ribosome biogenesis and protein synthesis by stabilizing the ribosomal structure and facilitating translational elongation. Common aliases include L6 and RPL6P1.
Dysregulation of RPL6 is linked to cancer progression, with overexpression observed in colorectal and lung cancers, potentially via enhancing tumor cell proliferation and survival. It interacts with the mTOR signaling pathway, influencing ribosomal biogenesis and cell growth. Currently, no specific drugs targeting RPL6 are in clinical development, but its role in ribosomal function makes it a potential therapeutic target for cancer treatment.