SIRT3, a crucial deacetylase enzyme residing in mitochondria, comprises a catalytic domain flanked by N-terminal and C-terminal structures that regulate its enzymatic activity. Upon cellular stress, SIRT3 translocates to mitochondria and matures, enabling it to perform its deacetylase function. SIRT3 plays a pivotal role in fat metabolism by modulating mitochondrial structure and function, such as activating long-chain acyl-CoA dehydrogenase. In terms of signaling pathways, SIRT3 inhibits the expression of NLRP3 inflammasomes by regulating the GSK-3β/β-catenin signaling pathway, thereby protecting bone osteogenesis. Additionally, in kidney diseases, SIRT3 suppresses renal fibrosis and regulates energy metabolism homeostasis through its deacetylase activity. Furthermore, SIRT3 is involved in physiological and pathological processes such as cardiac oxidative stress and ischemic reperfusion injury.
The following SIRT3 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
SIRT3 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA882102ESR1HU | SIRT3 Antibody |
Human | ELISA, WB, IHC |
CSB-PA882102ESR2HU | SIRT3 Antibody |
Human | ELISA, WB, IHC |
CSB-PA229200 | SIRT3 Antibody |
Human | ELISA,WB |
CSB-PA008365 | SIRT3 Antibody |
Human | WB, ELISA |
CSB-PA100396 | SIRT3 Antibody |
Human,Mouse | ELISA,IHC |
CSB-PA937428 | SIRT3 Antibody |
Human,Mouse | ELISA,WB,IHC |
CSB-PA882102LA01HU | SIRT3 Antibody |
Human, Mouse | ELISA, WB, IF |
CSB-PA882102LD01HU | SIRT3 Antibody, Biotin conjugated |
Human | ELISA |
CSB-PA882102LB01HU | SIRT3 Antibody, HRP conjugated |
Human | ELISA |
SIRT3 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP882102HU CSB-EP882102HU CSB-BP882102HU CSB-MP882102HU CSB-EP882102HU-B |
Recombinant Human NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP882102HU1 | Recombinant Human NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3), partial |
E.coli |
CSB-EP882102HU1(M) | Recombinant Human NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3) (R235A,E246A), partial |
E.coli |
CSB-EP882102HU2(M) | Recombinant Human NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3) (R235A,E246A), partial |
E.coli |
SIRT3 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL021341HU | Human NAD-dependent deacetylase sirtuin-3, mitochondrial(SIRT3) ELISA kit |
serum, plasma, tissue homogenates | 3.9 pg/mL |