SMARCA5

SMARCA5, SWI/SNF-related matrix-associated action protein A5, is also known as SNF2L, BAF170, or hBRM. it is a protein encoded by the SMARCA5 gene and is a member of the SWI/SNF chromatin remodelling complex.SMARCA5 functions in the nucleus, and its mechanism of action involves the use of energy from the hydrolysis of ATP to alter the chromatin structure, thereby regulating gene transcription. It increases or decreases the accessibility of transcription factors to DNA by sliding or remodelling nucleosome positions.SMARCA5 is involved in signalling pathways that include a variety of cell cycle regulation, cell proliferation, differentiation and DNA damage response processes.

In a biological sense, SMARCA5 is essential for maintaining genomic stability, regulating cell fate and participating in developmental processes. Its aberrant expression or loss of function has been associated with the development of a variety of tumours. Especially in certain types of cancers, mutations in SMARCA5 are closely associated with tumour aggressiveness and prognosis, making it a potential target for cancer research and therapy.