SMARCAL1

SMARCAL1, also known as SNF2-related chromatin remodeling annealing helicase 1, is a DNA translocase that plays a crucial role in DNA replication and repair. It functions by reattaching the two strands of DNA's double helix, allowing replication to proceed. SMARCAL1 is involved in the DNA damage response and chromatin regulation, maintaining genome stability and controlling gene expression. It interacts with various signaling pathways, including the cGAS-STING pathway and PD-L1 regulation, and is associated with diseases such as Schimke immune-osseous dysplasia and cancer. Research on SMARCAL1 has led to potential therapeutic targets for cancer immunotherapy, focusing on its role in tumor immune evasion and DNA damage response.