SORT1

Sortilin is a protein in humans that is encoded by SORT1 gene. Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs).

SORT1 Antibodies

SORT1 Antibodies for Homo sapiens (Human)

SORT1 Antibodies for Rattus norvegicus (Rat)

SORT1 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)

SORT1 Proteins

SORT1 Proteins for Rattus norvegicus (Rat)

SORT1 Proteins for Mus musculus (Mouse)

SORT1 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

SORT1 Proteins for Homo sapiens (Human)

SORT1 ELISA Kit

SORT1 ELISA Kit for Homo sapiens (Human)

SORT1 ELISA Kit for Mus musculus (Mouse)

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