STK19

STK19, also known as serine/threonine kinase 19, has alternative names such as G11, RP1, and D6S60. Initially thought to be a protein kinase associated with NRAS-driven melanoma, subsequent research revealed that it lacks kinase activity and is instead a DNA/RNA binding protein with three closely packed winged helix domains.
STK19 interacts with repair factors like DNA and RNA polymerase II subunit RPB1, CSA, and UVSSA, participating in the formation of transcription-coupled repair (TCR) complexes and playing a crucial role in TFIIH positioning and PolII clearance. STK19 is essential for DNA damage repair and cell proliferation, engaging in nucleotide excision repair (NER) and mismatch repair (MMR) pathways by recruiting damage repair factors such as RPA2 and PCNA. The discovery of STK19 has transformed our understanding of TCR mechanisms, providing important insights into the molecular mechanisms of human TCRs.

Popular Product:

Recombinant Human Serine/threonine-protein kinase 19 (STK19)