TCF3

TCF3, transcription factor 3, alias E2A immunoglobulin enhancer-binding protein, B-cell-specific transcription factor 3 (Bcl-3), etc. TCF3 is a basic helix-loop-helix (bHLH) structural domain transcription factor, belonging to the T-cell factor/lymphoid TCF3 is a basic helix-loop-helix (bHLH) structural domain transcription factor that belongs to the T-cell factor/lymphoid-binding factor (TCF/LEF) family. TCF3 is expressed in a variety of cell types and plays an important role in cell proliferation, differentiation, migration and apoptosis, etc. The mechanism of action of TCF3 involves interactions with a variety of proteins and DNA sequences, and is capable of regulating the expression of downstream genes.

TCF3 has a wide range of biological significance, which not only participates in the normal physiological process of the cell, but also closely relates to the development of a variety of diseases. As a major effector molecule in the Wnt/β-catenin signaling pathway, TCF3 regulates the transcription of target genes through interaction with β-catenin. In tumor cells, the expression level and activity of TCF3 are associated with tumor invasiveness, metastasis and drug resistance, making it a potential target for cancer therapy. In addition, TCF3 plays a role in stem cell maintenance and differentiation, affecting tissue regeneration and development. Therefore, the study of TCF3 not only helps us to understand its role in normal physiological processes, but also provides new perspectives for the diagnosis and treatment of diseases.