TMEM132B

TMEM132B, a transmembrane protein also identified as RGD1566191, is broadly present in the human body with significant expression in the brain. This protein interacts with GABAA receptors, amplifying the positive allosteric influence of alcohol on these receptors and managing the dynamics of GABAA receptor ion channels. TMEM132B is pivotal in governing alcohol-related behaviors; mice lacking the TMEM132B gene show higher alcohol intake and diminished responses to alcohol's sedative and hypnotic effects. Understanding TMEM132B's role offers new molecular insights into how alcohol affects brain function and could guide therapeutic approaches for alcohol addiction and the new drug development.

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combinant Human Transmembrane protein 132B (TMEM132B), partial