TMEM33

Transmembrane Protein 33 (TMEM33), also known as FLJ10213, is an endoplasmic reticulum (ER)-resident transmembrane protein. It modulates calcium homeostasis by interacting with inositol 1,4,5-trisphosphate receptors (IP3Rs), regulating ER calcium release. This function links it to the unfolded protein response (UPR) pathway, where it helps mitigate ER stress by fine-tuning calcium signaling dynamics.
TMEM33 dysregulation is associated with neurodegenerative diseases (e.g., Alzheimer’s) due to impaired ER stress resolution, and cardiovascular disorders from calcium signaling disruptions. While no targeted therapies are approved yet, preclinical research is investigating small molecules targeting TMEM33-IP3R interactions to restore ER homeostasis in disease models.

Popular Product:

TMEM33 Antibody (CSB-PA023829LA01HU)

Validated Data

Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA023829LA01HU at dilution of 1:100

Immunofluorescent analysis of Hela cells using CSB-PA023829LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

The following TMEM33 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

TMEM33 Antibodies

TMEM33 Proteins

TMEM33 Antibodies

TMEM33 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA023829LC01HU	TMEM33 Antibody, FITC conjugated	Human
CSB-PA023829LB01HU	TMEM33 Antibody, HRP conjugated	Human	ELISA
CSB-PA023829LA01HU	TMEM33 Antibody	Human	ELISA, IHC, IF

TMEM33 Proteins

TMEM33 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-CF023829HU	Recombinant Human Transmembrane protein 33 (TMEM33)	in vitro E.coli expression system
CSB-YP023829HU1 CSB-EP023829HU1 CSB-BP023829HU1 CSB-MP023829HU1 CSB-EP023829HU1-B	Recombinant Human Transmembrane protein 33 (TMEM33), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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