TNFRSF9, also known as 4-1BB or CD137, is a member of the tumor necrosis factor (TNF) receptor superfamily. TNFRSF9 is a type II membrane glycoprotein with a molecular weight of 30 kDa. It is a receptor for TNFSF9/4-1BBL, which is a type II glycoprotein with a mass of 34 kDa and has been identified as the ligand of TNFRSF9 through an expression cloning approach.
The binding of TNFRSF9 with TNFSF9 contributes to the TNFRSF9 activation and initiates a complex set of intracellular signaling pathways. As presented in Figure 3, TNFSF9 is expressed on APCs, B cells, macrophages, and other cell types, which binds with TNFRSF9 to induce diverse signaling through TRAF1 and TRAF2. These signaling pathways promote the expression of survival genes including Bcl-2, Bcl-XL, and Bfl-1 and inhibit the expression of pro-apoptotic Bim. Nevertheless, crosslinking of TNFRSF9 with TNFSF9 induces various immune responses involving both adaptive and innate immunity. Because binding between TNFRSF9 and TNFSF9 on various cells can trigger bidirectional signals, it is difficult to dissect the individual effects of them.
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Validated Data
Greater than 95% as determined by SDS-PAGE.
Immobilized TNFRSF9 at 2 μg/ml can bind TNFSF9 (CSB-MP023997HU1), the EC50 is 1.011-2.429 ng/mL.
The following TNFRSF9 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
TNFRSF9 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA011218 | TNFRSF9 Antibody |
Human | WB, IF, ELISA |
CSB-PA983768 | TNFRSF9 Antibody |
Human | ELISA,IHC |
CSB-PA718806 | TNFRSF9 Antibody |
Human | IHC,ELISA |
CSB-PA08109A0Rb | TNFRSF9 Antibody |
Human | ELISA, WB, IF |
CSB-PA08109B0Rb | TNFRSF9 Antibody, HRP conjugated |
Human | ELISA |
CSB-PA08109C0Rb | TNFRSF9 Antibody, FITC conjugated |
Human | |
CSB-PA08109D0Rb | TNFRSF9 Antibody, Biotin conjugated |
Human | ELISA |
CSB-RA023984A1HU | TNFRSF9/4-1BB Monoclonal Antibody |
Human | ELISA |
TNFRSF9 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-AP001951HU | Recombinant Human Tumor necrosis factor receptor superfamily member 9 protein(TNFRSF9),Partial (Active) |
E.Coli |
CSB-AP005131HU | Recombinant Human Tumor necrosis factor receptor superfamily member 9(TNFRSF9),partial (Active) |
Mammalian cell |
CSB-AP005141HU | Recombinant Human Tumor necrosis factor receptor superfamily member 9(TNFRSF9),partial (Active) |
Mammalian cell |
CSB-AP005151HU | Recombinant Human Tumor necrosis factor receptor superfamily member 9(TNFRSF9),partial (Active) |
Mammalian cell |
CSB-MP023984HU1 | Recombinant Human Tumor necrosis factor receptor superfamily member 9(TNFRSF9),partial (Active) |
Mammalian cell |
TNFRSF9 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-CF023984MO | Recombinant Mouse Tumor necrosis factor receptor superfamily member 9(Tnfrsf9) |
in vitro E.coli expression system |
CSB-YP023984MO1 CSB-EP023984MO1 CSB-BP023984MO1 CSB-MP023984MO1 CSB-EP023984MO1-B |
Recombinant Mouse Tumor necrosis factor receptor superfamily member 9(Tnfrsf9),partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TNFRSF9 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL023984HU | Human Tumor necrosis factor receptor superfamily member 9(TNFRSF9) ELISA kit |
serum, plasma, tissue homogenates | 1.95 pg/mL |
TNFRSF9 ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL023984MO | Mouse Tumor necrosis factor receptor superfamily member 9(TNFRSF9) ELISA kit |
serum, plasma, tissue homogenates | 3.9 pg/ml |