TNFRSF9 Research Reagents

TNFRSF9, also known as 4-1BB or CD137, is a member of the tumor necrosis factor (TNF) receptor superfamily. TNFRSF9 is a type II membrane glycoprotein with a molecular weight of 30 kDa. It is a receptor for TNFSF9/4-1BBL, which is a type II glycoprotein with a mass of 34 kDa and has been identified as the ligand of TNFRSF9 through an expression cloning approach.

The binding of TNFRSF9 with TNFSF9 contributes to the TNFRSF9 activation and initiates a complex set of intracellular signaling pathways. As presented in Figure 3, TNFSF9 is expressed on APCs, B cells, macrophages, and other cell types, which binds with TNFRSF9 to induce diverse signaling through TRAF1 and TRAF2. These signaling pathways promote the expression of survival genes including Bcl-2, Bcl-XL, and Bfl-1 and inhibit the expression of pro-apoptotic Bim. Nevertheless, crosslinking of TNFRSF9 with TNFSF9 induces various immune responses involving both adaptive and innate immunity. Because binding between TNFRSF9 and TNFSF9 on various cells can trigger bidirectional signals, it is difficult to dissect the individual effects of them.

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Popular Product

Recombinant Human Tumor necrosis factor receptor superfamily member 9(TNFRSF9),partial (Active) (CSB-MP023984HU1)

Validated Data

Purity determined
by SDS-PAGE

Greater than 95% as determined by SDS-PAGE.

The binding activity of TNFSF9-TNFRSF9 validated by functional ELISA

Immobilized TNFRSF9 at 2 μg/ml can bind TNFSF9 (CSB-MP023997HU1), the EC₅₀ is 1.011-2.429 ng/mL.