TOP2

TOP2, as a topoisomerase II, plays a crucial role in DNA replication and transcription. Its complex protein structure endows it with specific catalytic and DNA binding abilities, enabling it to accurately recognize and bind to DNA. During DNA replication, TOP2 ensures the smooth progression of the replication process by solving the "topological problems" caused by topological structure changes. Similarly, during transcription, TOP2 also plays a similar role, ensuring the smooth transcription of RNA polymerase. In addition, the activity of TOP2 is regulated by various factors and signaling molecules, and abnormal regulation can lead to the occurrence of related diseases.