TRAM1

TRAM1, translocation-associated membrane protein 1, alias TRAM, PNAS8, TRAMP. It is a multichannel membrane protein expressed in the endoplasmic reticulum of human cells.
The mechanism of action of TRAM1 involves affecting glycosylation and facilitating the translocation of secreted proteins across endoplasmic reticulum membranes by regulating which structural domains are visible to cytoplasmic lysates during translocation pauses of nascent polypeptide chains. It may also affect the phospholipid bilayer in the vicinity of the SEC61 channel, which promotes endoplasmic reticulum transport of proteins and is involved in protein degradation during the unfolded protein response (UPR) under conditions of endoplasmic reticulum stress.
TRAM1 plays a role in a wide variety of biological processes, including host-virus interactions, protein transport, translocation, and the unfolded protein response. Aberrant TRAM1 expression has been associated with a variety of diseases, such as Meckel syndrome type 2, Oropouche fever, neuronal lipofuscin deposition disorder type 8 Northern epilepsy variant, and Varadi-Papp syndrome.

Popular Product:

Recombinant Human Translocating chain-associated membrane protein 1 (TRAM1), partial