TRBC1, also known as T-cell receptor beta chain constant domain 1, is a crucial component of the T-cell antigen receptor (TCR). The TCR, a heterodimer fixed on the cell membrane, mostly consists of highly variable α and β subunits connected through disulfide bonds. T-cells with this structure are referred to as αβ T-cells. Each subunit contains two extracellular domains: a variable region and a constant region. TRBC1 specifically represents a part of the constant region of the β subunit. TRBC1 plays a pivotal role in T-cell activation signaling. When the TCR recognizes and binds to an antigen, it forms a T-cell receptor complex with the constant CD3 molecule, triggering a series of intracellular signaling events that ultimately lead to T-cell activation. Upon antigen binding, the TCR transduces signals into the T-cell through the CD3 molecule, activating a cascade of kinases and phosphatases. This ultimately initiates biological effects such as gene transcription and protein synthesis, enabling T-cell activation, proliferation, and differentiation.
Recombinant Human T cell receptor beta constant 1 (TRBC1), partial
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
The following TRBC1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
TRBC1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA024291LA01HU | TRBC1 Antibody |
Human | ELISA, IHC, IF |
CSB-PA024291LB01HU | TRBC1 Antibody, HRP conjugated |
Human | ELISA |
CSB-PA024291LC01HU | TRBC1 Antibody, FITC conjugated |
Human | |
CSB-PA024291LD01HU | TRBC1 Antibody, Biotin conjugated |
Human | ELISA |
CSB-PA004251 | TRBC1 Antibody |
Human | WB, ELISA |
TRBC1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP024291HU | Recombinant Human T cell receptor beta constant 1 (TRBC1), partial |
Yeast |
CSB-CF024291HU | Recombinant Human T cell receptor beta constant 1 (TRBC1), partial |
in vitro E.coli expression system |
CSB-BP024291HU1 CSB-MP024291HU1 |
Recombinant Human T cell receptor beta constant 1 (TRBC1), partial |
Baculovirus Mammalian cell |
CSB-EP024291HU1 | Recombinant Human T cell receptor beta constant 1 (TRBC1), partial |
E.coli |
CSB-EP024291HU1-B | Recombinant Human T cell receptor beta constant 1 (TRBC1), partial,Biotinylated |
E.coli |