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von Hippel-Lindau disease tumor suppressor is a protein in humans that is encoded by VHL gene. Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2.
The following VHL reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
VHL Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA060066 | Phospho-VHL (S68) Antibody |
Human,Mouse,Rat | IHC, ELISA |
| CSB-PA060067 | VHL Antibody |
Human,Mouse,Rat | IHC, ELISA |
| CSB-PA991849 | VHL Antibody |
Human | ELISA,IHC |
| CSB-PA071125 | VHL Antibody |
Human | ELISA,WB,IHC |
| CSB-PA876839 | VHL Antibody |
Human | IHC,ELISA |
| CSB-PA025852ZA01HU | VHL Antibody |
Homo sapiens | ELISA, WB (ensure identification of antigen) |
VHL Antibodies for Drosophila melanogaster (Fruit fly)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA893700XA01DLU | Vhl Antibody |
Drosophila melanogaster (Fruit fly) | ELISA, WB (ensure identification of antigen) |
VHL Proteins for Mus musculus (Mouse)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP025852MO CSB-EP025852MO CSB-BP025852MO CSB-MP025852MO CSB-EP025852MO-B |
Recombinant Mouse Von Hippel-Lindau disease tumor suppressor(Vhl) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VHL Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP025852HU CSB-BP025852HU CSB-MP025852HU |
Recombinant Human Von Hippel-Lindau disease tumor suppressor(VHL) |
Yeast Baculovirus Mammalian cell |
| CSB-EP025852HU | Recombinant Human Von Hippel-Lindau disease tumor suppressor(VHL) |
E.coli |
VHL Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP715952DO CSB-EP715952DO CSB-BP715952DO CSB-MP715952DO CSB-EP715952DO-B |
Recombinant Dog Von Hippel-Lindau disease tumor suppressor(VHL) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VHL Proteins for Rattus norvegicus (Rat)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP727052RA CSB-EP727052RA CSB-BP727052RA CSB-MP727052RA CSB-EP727052RA-B |
Recombinant Rat Von Hippel-Lindau disease tumor suppressor(Vhl) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VHL Proteins for Drosophila melanogaster (Fruit fly)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP893700DLU CSB-EP893700DLU CSB-BP893700DLU CSB-MP893700DLU CSB-EP893700DLU-B |
Recombinant Drosophila melanogaster Protein Vhl(Vhl) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
