VPS35

VPS35, also known as Vacuolar Protein Sorting 35, is a core component of the retromer complex. It plays a crucial role in endosomal protein sorting and trafficking, retrieving selected proteins from endosomes back to the trans - Golgi network or the plasma membrane. This process is essential for maintaining proper cellular function. It is involved in the Wnt signaling pathway and plays a role in maintaining the balance of membrane - associated proteins.
Mutations in VPS35 have been linked to various neurodegenerative diseases, particularly Parkinson's disease. Given its importance in disease - related pathways, VPS35 has become a promising target for drug development. Currently, researchers are exploring small molecules and biologics that can modulate its function, aiming to develop novel therapies for these associated disorders.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP839401HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) VPS35.

VPS35 Antibody (CSB-PA839401ESR2HU)

Validated Data

Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA839401ESR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA839401ESR2HU at dilution of 1:100

The following VPS35 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

VPS35 Antibodies

VPS35 Proteins

VPS35 Antibodies

VPS35 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA088155	VPS35 Antibody	Human,Mouse	ELISA,WB,IHC
CSB-PA076908	VPS35 Antibody	Human,Mouse	ELISA,IHC
CSB-PA839401ESR2HU	VPS35 Antibody	Human	ELISA, IHC

VPS35 Antibodies for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Code	Product Name	Species Reactivity	Application
CSB-PA025904XA01SVG	VPS35 Antibody	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	ELISA, WB (ensure identification of antigen)

VPS35 Antibodies for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Code	Product Name	Species Reactivity	Application
CSB-PA025904XA01SXV	vps35 Antibody	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	ELISA, WB (ensure identification of antigen)

VPS35 Proteins

VPS35 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Code	Product Name	Source
CSB-YP025904SVG CSB-EP025904SVG CSB-BP025904SVG CSB-MP025904SVG CSB-EP025904SVG-B	Recombinant Saccharomyces cerevisiae Vacuolar protein sorting-associated protein 35 (VPS35), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

VPS35 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Code	Product Name	Source
CSB-YP025904SXV CSB-EP025904SXV CSB-BP025904SXV CSB-MP025904SXV CSB-EP025904SXV-B	Recombinant Schizosaccharomyces pombe Vacuolar protein sorting-associated protein 35 (vps35), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

VPS35 Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP642243BO CSB-EP642243BO CSB-BP642243BO CSB-MP642243BO CSB-EP642243BO-B	Recombinant Bovine Vacuolar protein sorting-associated protein 35 (VPS35), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

VPS35 Proteins for Dictyostelium discoideum (Slime mold)

Code	Product Name	Source
CSB-YP681538DKK CSB-EP681538DKK CSB-BP681538DKK CSB-MP681538DKK CSB-EP681538DKK-B	Recombinant Dictyostelium discoideum Vacuolar sorting protein 35 (vps35), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

VPS35 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP839401HU CSB-BP839401HU CSB-MP839401HU CSB-EP839401HU-B	Recombinant Human Vacuolar protein sorting-associated protein 35 (VPS35)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP839401HU	Recombinant Human Vacuolar protein sorting-associated protein 35 (VPS35)	E.coli
CSB-BP839401HUd8	Recombinant Human Vacuolar protein sorting-associated protein 35 (VPS35)	Baculovirus

VPS35 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP863646MO CSB-EP863646MO CSB-BP863646MO CSB-MP863646MO CSB-EP863646MO-B	Recombinant Mouse Vacuolar protein sorting-associated protein 35 (Vps35)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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VPS35

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