ZDHHC2

ZDHHC2, also known as palmitoyltransferase 2, is a member of the DHHC protein family. It plays a crucial role in the palmitoylation of proteins, a post-translational modification that affects protein localization, trafficking, and function. ZDHHC2 is involved in various signaling pathways, including those related to synaptic plasticity and neuronal development. Its dysregulation has been linked to schizophrenia, a complex psychiatric disorder. Research on ZDHHC2 has identified potential drug targets for schizophrenia, highlighting its significance in neuropsychiatric diseases.
ZDHHC2's function in the palmitoylation of synaptic proteins like PSD-95 and AKAP79/150 is pivotal for synaptic plasticity and neuronal communication. Mutations in ZDHHC2 have been associated with schizophrenia, suggesting its involvement in the pathophysiology of this disorder. Recent studies have explored the potential of modulating ZDHHC2 activity as a therapeutic strategy for schizophrenia, offering new avenues for drug development.