Recombinant Human Interleukin-13 protein(IL13) (Active)

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Code CSB-AP001831HU
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Product Details

Purity >97% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Activity Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 1 ng/ml, corresponding to a specific activity of >1.0x106 IU/mg.
Target Names IL13
Uniprot No. P35225
Research Area Immunology
Alternative Names Allergic rhinitis; ALRH; BHR 1; BHR1; Bronchial hyperresponsiveness 1 (bronchial asthma); IL 13; IL-13; Il13; IL13_HUMAN; Interleukin 13; Interleukin-13; interleukin13; MGC116786; MGC116788; MGC116789; NC 30; NC30; P 600; P600
Species Homo sapiens (Human)
Source E.coli
Expression Region 35-146aa
Complete Sequence GPVPPSTALR ELIEELVNIT QNQKAPLCNG SMVWSINLTA GMYCAALESL INVSGCSAIE KTQRMLSGFC PHKVSAGQFS SLHVRDTKIE VAQFVKDLLL HLKKLFREGR FN
Mol. Weight 12.5 kDa
Protein Length Full Length of Mature Protein
Tag Info Tag-Free
Form Lyophilized powder
Buffer Lyophilized from a 0.2 µm filtered PBS, pH 7.4
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Basically, we can dispatch the products out in 5-10 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Cytokine
Gene References into Functions
  1. forced expression of miR16 blocked NFkappaB signaling by decreasing the expression of nuclear pp65 and pIkappaBalpha, as well as increasing the expression of IkappaBalpha in IL13treated nasal epithelial cells. PMID: 30132525
  2. These studies suggest that cellular NO excretion by the healthy epithelial mucosa is subject to considerable individual variability and may be significantly elevated among some individuals in the presence of IL-13 PMID: 29380192
  3. This study demonstrates that IL-13 serum levels are elevated in patients with insulin resistance without showing correlation with parameters of low-grade systemic inflammation. PMID: 29675435
  4. Our findings suggest that IL-13 SNP rs20541 is significantly associated with AR risk in Asians but not in Caucasians. [meta-analysis] PMID: 29687183
  5. genetic variants in IL-13, especially h0011 haplotype increased the risk of the prevalence of aggregate bronchitic symptoms in non-asthmatic children. It may also modify the effects of exposure to air pollutants on the prevalence of aggregate bronchitic symptoms. PMID: 29456163
  6. meta-analysis indicates 1112 polymorphism may be associated with susceptibility to periodontitis PMID: 29415708
  7. These results demonstrate that histamine up-regulates the expression of TLR3 and secretion of IL-13 and MCP-1 in mast cells, thus identifying a new mechanism for the histamine inducing allergic response. PMID: 29742501
  8. IL-13 enhances mesenchymal transition of pulmonary artery endothelial cells via down-regulation of miR-424/miR-503 in vitro. PMID: 29102771
  9. Silencing DUOX1 by siRNA attenuated IL-13-mediated increases in superoxide, but did not reduce autophagy activities. PMID: 28982074
  10. this is the first study using population epidemiological methods to elucidate the role of gut microbiota-related dietary factors and polymorphisms in miRNA-binding site in IL13 in CRC. PMID: 28537887
  11. Substitutions in the central immune regulator IL13 correspond to a polymorphism linked to asthma susceptibility in humans. PMID: 28854632
  12. IL13 polymorphism rs1295686 (in complete linkage disequilibrium with functional variant rs20541) is associated with challenge-proven food allergy. PMID: 28544327
  13. SOCS1 inhibits epithelial IL-13 signalling, supporting its key role in regulating Th2-driven eosinophilia in severe asthma PMID: 27338192
  14. IL-13, IL-13Ralpha1, STAT6 and ZEB1 have roles in promoting epithelial-mesenchymal transition and aggressiveness of colorectal cancer cells PMID: 27533463
  15. This meta-analysis suggests that the T allele of rs1800925 is associated with the increased risk of COPD in both Asians and Caucasians, whereas rs20541 is associated with the risk of COPD in Caucasians but not in Asians. PMID: 29381928
  16. the IL13-1112 C/T (rs1800925) polymorphism does not predict responsiveness to neoadjuvant chemoradiotherapy or prognosis of Chinese Han patients with locally advanced rectal cancer . PMID: 27167201
  17. The results of this study demonstrate that IL13QD can serve as an ex vivo marker for glioma stem cells and exosomes that can inform diagnosis and prognosis of patients harboring malignant disease. PMID: 28583903
  18. Different genotype profiles of IL13 gene seem to influence the clinical pattern of disease expression mainly confined to the upper airways, as rhinitis, or including the lower airways, as asthma PMID: 27561723
  19. secretion of IL-13 and amphiregulin suggests Intrahepatic Innate lymphoid cells may be recruited to promote resolution and repair and thereby they may contribute to ongoing fibrogenesis in liver disease. PMID: 29261670
  20. These findings demonstrate that NF-kappaB-mediated transcriptional mechanisms are critically involved in the IL-1beta-mediated IL-17C induction, and that IL-13 negatively regulates this induction by suppressing NF-kappaB-based transcriptional activation. PMID: 29203240
  21. These results suggested that IL-13 +1923C/T polymorphism contributed to the development of asthma. PMID: 28057889
  22. IL13 AA of rs20541 and STAT4 TT of rs925847 are potential genomic biomarkers for predicting lower pulmonary function. The administration of high-dose ICSs to asthmatic patients with genetic variants of IL13 AA may inhibit the advancement of airway remodelling. The genetic variants of STAT4 TT did not respond to high-dose ICSs. PMID: 26765219
  23. The diagnostic performance of sputum IL-13 was superior to both sputum eosinophils and FeNO levels for the identification of well-controlled asthma. Sputum IL-13 levels could serve as a useful biomarker for asthma control assessment. PMID: 26990030
  24. 15LO1 inhibition (by short interfering RNA and chemical inhibitor) decreased IL-13-induced forkhead box protein A3 (FOXA3) expression and enhanced FOXA2 expression. These changes were associated with reductions in both mucin 5AC and periostin. PMID: 28723225
  25. Clarithromycin suppressed IL-13-induced periostin production in human lung fibroblasts, in part by inhibiting STAT6 phosphorylation. This suggests a novel mechanism of the immunomodulatory effect of clarithromycin in asthmatic airway inflammation and fibrosis. PMID: 28219384
  26. Simvastatin reversed IL-13-suppressed adenosine deaminase activity, leading to the down-regulation of adenosine signaling and inhibition osteopontin expression through the direct inhibition of IL-13-activated STAT6 pathway in COPD. PMID: 27557561
  27. IL-13 suppressed cyp27b1 expression in CD14(+) cells. IL-13 increased expression of miR-19a in CD14(+) cells. IL-13 suppresses cyp27b1 expression in peripheral CD14(+) cells via up regulating miR-19a expression. PMID: 27381199
  28. Leptin knockdown suppressed MUC5AC production and secretion induced by IL-13 in human bronchial epithelial cells. PMID: 28942146
  29. demonstrate a strong association between the ratio of Acinetobacter to Proteobacteria and IL-13 production and the probability of IL-13 production after allergen exposure. IL-13 concentrations in serum were also significantly correlated with the diversity of bacterial DNA. Together, these results underscore the relationship between immune responses to allergens and bacterial exposure during perinatal development. PMID: 28443674
  30. These observations suggest that mechanical stretch may induce an influx of Ca(2+) and up-regulation of IL-13 and MMP-9 expression in 16HBE cells via activation of TRPC1 PMID: 27986325
  31. The presented data substantiate the hypothesis that claudin-18 is a central barrier-forming component of tight junctions and show that IL-13 downregulates claudin-18. These data also suggest that the loss of claudin-18 is associated with increased sensitization to aeroantigens and airway responsiveness PMID: 27215490
  32. investigated the role of six potentially functional variants of the IL4, IL13, and IL4R genes in gastrointestinal cancer; both IL13 rs20541 and rs1800925 were not associated with gastrointestinal cancer risk for any of the genetic models and subgroup analyses [meta-analysis] PMID: 28142034
  33. IL13 in bronchial epithelial cells and bronchial alveolar lavage fluid, rather than RAD50, IL4, or IL5, is more likely to be the asthma susceptibility gene. PMID: 27050946
  34. We also found that the activation of H4R caused the release of IL-13 and RANTES on human mast cells.these data demonstrate that the H4R activates divergent signaling pathways to induce cytokine and chemokine production in human mast cells PMID: 27400655
  35. IL13 Arg130Gln genotypes can play a role in genetic susceptibility to allergy via regulation of serum total IgE levels and affecting IFN-gamma gene expression. PMID: 28054352
  36. The GG genotype of IL-13 130A/G cytokine gene might be involved in the induced production of total IgE and IL-13 cytokine serum levels suggesting IL-13 may be important in the signalling of asthma. PMID: 28083766
  37. STAT6-TMEM16A-ERK1/2 signal pathway and TMEM16A channel activity are required for the IL-13-induced TMEM16A mediated mucus production PMID: 27588910
  38. TGF-beta- and IL-13-producing mast cells might be key players in the development of bone marrow fibrosis. PMID: 28159675
  39. this study shows that low expression of tristetraprolin is associated with glioma growth and metastasis by targeting IL-13 PMID: 27424080
  40. this study shows that IL-13 gene polymorphism is associated with allergic rhinitis and/or allergic conjunctivitis in Finnish asthma patients PMID: 28273659
  41. The presence of higher IL-13 and IL-17 serum levels in patients, compared with those of controls, confirms that these markers, found with high specificity, might be involved in the pathogenesis of eRA. IL-13 and IL-17 might be of better usefulness in the prediction of eRA activity status than IgM-RF and anti-CCP. PMID: 27579330
  42. The IL13 rs20541 T allele and IL28B rs8099917 GG genotype are negative predictors of survival in patients on renal replacement therapy PMID: 26039912
  43. these data suggest that microRNA-143 suppresses IL-13 activity and inflammation through targeting of IL-13Ralpha1 in epidermal keratinocytes PMID: 27048505
  44. Platycodin D inhibits IL-13-induced expression of inflammatory cytokines and mucus in nasal epithelial cells by inhibiting the activation of NF-kappaB and MAPK signaling pathways. PMID: 27780139
  45. A negative correlation between IL-13Ra2 and IL-13 was found during early infection of human schistosomiasis, suggesting an increase in cytokine in early fibrosis. PMID: 27507682
  46. autophagy is essential for airway mucus secretion in a type 2, IL13-dependent immune disease process. PMID: 26062017
  47. childhood asthma is associated with gene polymorphism; meta-analysis PMID: 26534891
  48. PLD1 activation enhanced binding of ROCK1 to ATF-2 and leads to increased expression of IL-13 PMID: 26335962
  49. DNA hypomethylation of IL13 gene may be associated with increased risk of allergic rhinitis from house dust mite sensitization PMID: 26399722
  50. Our in vitro and in vivo data indicate close cooperation between mechanical and inflammatory stimuli on TF expression and release of TF-positive extracellular vesicles in the lungs, which may contribute to pathophysiology of asthma PMID: 26407210
  51. Data show that single nucleotide polymorphisms (SNPs) rs848 in the interleukin 13 (IL13) gene region is significantly associated with a continuous measure of symptom severity in adult subjects with ever asthma. PMID: 26986948
  52. Lack of association between RAD50-IL13 polymorphisms and pediatric asthma susceptibility in Northeastern Han Chinese PMID: 26365633
  53. These in vitro data imply that IL-13-treated skin equivalent model exhibited atopic dermatitis-like features and that IL-13 may have a role in basement membrane defects. PMID: 25065568
  54. IL-13 is a type 2 cytokine that is a key mediator of airway inflammation and remodeling in many inflammatory diseases of the lung, such as asthma. Read More: http://www.atsjournals.org/doi/full/10.1164/rccm.201506-1243OC#.V2bnHdLrtNs PMID: 26474238
  55. The IL13 haplotype rs1800925T-rs20541C increased the risk of disease progression to late-stage schistosomiasis, whereas haplotype rs1800925C-rs20541A showed a protective role against development of late-stage schistosomiasis. PMID: 26258681
  56. IL-13 induces miR-142-5p and downregulates miR-130a-3p in macrophages, regulating macrophage profibrogenic gene expression in chronic inflammation. PMID: 26436920
  57. Report altered expression of surfactant protein D in airways of asthmatics and interleukin-13 modulation of surfactant protein D in human models of airway epithelium. PMID: 25848896
  58. IL-13 may induce mitral valvular fibrosis rheumatic heart disease. PMID: 26897823
  59. IL-13 confers epithelial cell responsiveness to NGF by regulating NTRK1 levels by a transcriptional and epigenetic mechanism and that this process likely contributes to allergic inflammation. PMID: 25389033
  60. physiologic doses of interleukin-4 (IL-4) and interleukin-13 (IL-13) have profound anti-lymphangiogenic effects and potently impair LEC survival, proliferation, migration PMID: 26039103
  61. PAR-2-mediated IL-13 production by human monocytes may be dependent on the Ca2+/ERK2 signaling pathway. PMID: 25976462
  62. Immunostaining and semiquantitative analysis revealed increased presence of IL13 in the pulmonary vasculature of patients with connective tissue disease-associated PAH and Schistosoma-PAH compared with normal control subjects. PMID: 26192556
  63. rs2158177 polymorphism of the IL-13 gene is associated with asthma in ethnic Han Chinese from Qingdao. No association has been found between polymorphisms of TNF-alpha gene with susceptibility to asthma. PMID: 26418997
  64. GM-CSF primes IL-13 production by macrophages via PAR-2. PMID: 25633855
  65. IL-13/STAT6 signaling is modulated by Kaposi's sarcoma-associated herpesvirus to promote host cell proliferation and viral pathogenesis. PMID: 26246572
  66. IL-13 G+2044A polymorphism might not contribute to the susceptibility associated with a risk of chronic obstructive pulmonary disease. [meta-analysis] PMID: 24990692
  67. IL-13 interacts with hyper-radiosensitive cells though receptor IL-13Ralpha2 and induces upregulation of iNOS and activation of one or more furin-like proprotein convertases. PMID: 24966400
  68. increased protein levels are associated with increased histone acetylation in childhood allergic asthma PMID: 25769912
  69. regulates gene expression in IL-33-activated mast cells and type 2 innate lymphoid cells thus contributing to fibrosis, eosinophilia, and mucous metaplasia PMID: 25784274
  70. Patients with lymph node metastasis, lymphatic invasion, vascular invasion, distant metastases or advanced stage of disease had significantly lower serum IL-13 levels. PMID: 24833143
  71. IL-13 and its signaling mediators are novel markers of cutaneous T-cell lymphoma malignancy and potential therapeutic targets for intervention. PMID: 25628470
  72. The results of this meta-analysis suggest that IL13-1112C/T and +2044A/G polymorphisms contribute to the development of pediatric asthma. PMID: 25502839
  73. The results of this study suggest that these proteins play important roles in pulmonary inflammatory reactions elicited against etiological viral agents. PMID: 25453333
  74. IL-13 alters the expression of ZO-1, and such alterations in the content and distribution of ZO-1 may be relevant in the pathogenesis of proteinuria in the MCNS model. PMID: 25683991
  75. Increased level of IL13 is associated with the development of chronic rhinosinusitis with nasal polyps. PMID: 25674935
  76. There is an interaction between IL-13 (rs20541) and delivery mode with respect to the subsequent risk of atopic dermatitis in infancy. PMID: 24848505
  77. serum level not associated with pulmonary arterial hypertension in schistosomiasis PMID: 24886277
  78. Lack of association between the IL-13 C-1112T, G2044A polymorphisms and Graves' disease risk: evidence from a meta-analysis. PMID: 24564787
  79. Although basophils were recruited into liver granulomas, they appeared to be dispensable as a source of IL-4/IL-13 both for differentiation of Th2 cells and for prevention of weight loss and mortality. PMID: 25172500
  80. Inhibition of GATA3 activity or blockade of GATA3 expression may attenuate the interleukin-13 mediated asthma phenotypes. PMID: 24363163
  81. IL-13 potentiates airway remodelling through a mechanism involving collagen type I expression, TGF-beta1 and MMP-2 PMID: 23682108
  82. After allergens stimulation, CD4T cells showed an increase of IL-13 and IL-17 production. PMID: 24338253
  83. endogenously expressed IL-13Ralpha2 does not activate any unique IL-13-mediated gene expression patterns, confirming its role as a decoy receptor for IL-13 signaling. PMID: 24879793
  84. The rs1800925 T allele of the IL-13 gene is associated with worse pulmonary function in patients with Idiopathic pulmonary fibrosis. PMID: 23549736
  85. The role of IL-13 in driving fibrosis in systemic sclerosis and chronic inflammation. [Review] PMID: 23893513
  86. The polymorphism of the IL-13 gene is associated with an increased risk of COPD in southern Chinese Han population. Plasma IL-13 levels were found elevated in patients with COPD. PMID: 24286397
  87. We found an association between psoriasis and a single nucleotide polymorphism of the gene encoding IL-13 in Chinese Ugyur patients. PMID: 23617596
  88. IL-13 gene polymorphisms and their association with atopic asthma and rhinitis in Pakistani patients. PMID: 23996716
  89. associated with uterine fibroids in African American women living in the Detroit, Michigan area PMID: 23614810
  90. The dynamics of STIM1 aggregation and SOCE after exposure to TNF-alpha or IL-13 in ASM cells. PMID: 23713409
  91. This meta-analysis suggests IL-13 -1112 C/T promoter polymorphism is associated with the risk of COPD in Arabians. PMID: 23874547
  92. IL-13 is synthesized and released by skeletal muscle through a mechanism involving let-7, and this effect is attenuated in skeletal muscle from insulin-resistant T2 Diabetes mellitus patients. PMID: 24105413
  93. Higher levels of IL-13 in cord blood may be a predictor of future development of allergic sensitization PMID: 23754348
  94. the -1111T mutant allele are associated with asthma and the 4257A mutant alleles are associated with elevated IL-13 production. PMID: 23865080
  95. results confirmed the significant role of -1112 C/T IL-13 gene polymorphism in the pathogenesis of atopic dermatitis PMID: 23317483
  96. Data suggest that signal transduction between two cytokines, IL-13 and IL-6, and their respective receptors, IL13R and IL6R, results in rapid phosphorylation of two STAT transcription factors, STAT3 and STAT6, in pancreatic beta-cells. PMID: 23510983
  97. the genotype "TC" of rs20541 in IL-13 gene showed an increased risk of glioblastoma in over-dominant model (OR = 2.00; 95% CI, 1.13-3.54, p = 0.015) PMID: 23663500
  98. results from this meta-analysis suggested that IL-13 +1923C/T polymorphism was a risk factor of asthma. PMID: 23841068
  99. An meta-analysis suggests that the IL13 rs20541 polymorphism may be a genetic predictor for glioma. PMID: 23395224
  100. We demonstrated an increased proportion of IL-13/IL-22-coproducing T cells with skin-homing properties in the circulation of patients with atopic dermatitis. PMID: 24001799

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Involvement in disease Allergic rhinitis (ALRH)
Subcellular Location Secreted
Protein Families IL-4/IL-13 family
Database Links

HGNC: 5973

OMIM: 147683

KEGG: hsa:3596

STRING: 9606.ENSP00000304915

UniGene: Hs.845

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