Recombinant Human Interleukin-2(IL2)

In Stock
Code CSB-AP004381HU
Product Type Interleukin
Size US$65
Uniprot No. P60568
Lead Time 5-10 business days
Storage Buffer Lyophilized from a 0.2 μm Filtered 10 mM sodium citrate, pH 4.0
Alias Interleukin-2; IL-2; T-Cell Growth Factor; TCGF; Aldesleukin; IL2
Species Homo sapiens (Human)
Biological_Activity The ED50 as determined in a cell proliferation assay using CTLL?2 mouse cytotoxic T cells is less than 0.5 ng/ml.
Purity Greater than 95% as determined by SDS-PAGE.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT
Research Area Immunology
Source E.coli
Gene Names IL2
Expression Region 21-153aa
Tag Info Tag-Free
Mol. Weight 15.5 kDa
Protein Description Full Length of Mature Protein
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Function Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
Involvement in disease A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
Subcellular Location Secreted
Protein Families IL-2 family
Database Links

HGNC: 6001

OMIM: 147680

KEGG: hsa:3558

STRING: 9606.ENSP00000226730

UniGene: Hs.89679

Pathway Jak-STAT signaling pathway
PI3K-Akt signaling pathway
T cell receptor signaling pathway
Th1 and Th2 cell differentiation
Th17 cell differentiation

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