AMOT Antibody

Datasheet
Code CSB-PA001677GA01HU
Product Type Purified Rabbit Anti Human,Mouse,Rat PolyClonal Antibody
Size US$685
Uniprot No. Q4VCS5
Immunogen Human AMOT
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,WB
Storage Buffer PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method Antigen Affinity purified
Isotype IgG
Alias angiomotin;AMOT;KIAA1071 ;
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Target Names AMOT
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Details This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms.
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Function Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions.
Subcellular Location Cell junction, tight junction
Protein Families Angiomotin family
Tissue Specificity Expressed in placenta and skeletal muscle. Found in the endothelial cells of capillaries as well as larger vessels of the placenta.
Database Links

HGNC: 17810

OMIM: 300410

KEGG: hsa:154796

STRING: 9606.ENSP00000361027

UniGene: Hs.528051

Pathway Hippo signaling pathway

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