Recombinant Drosophila melanogaster Homeobox protein homothorax (hth)

1. The Ubx cofactor, Homothorax (Hth), was co-enriched with Ubx near enhancers that require Hth, even though Ubx and Hth did not co-localize throughout the nucleus. Thus, microenvironments of high local transcription factor and cofactor concentrations could help low-affinity sites overcome their kinetic inefficiency. PMID: 29095143
2. the satellite repeats get transcribed in wild type embryos and that this transcription depends on the presence of Hth, which binds to them as well as to the ribosomal DNA region. PMID: 25794008
3. Functional dissection of the splice variants of the Drosophila gene homothorax (hth PMID: 24075905
4. Hox genes and homothorax are required for motoneuron survival. PMID: 23536569
5. Loss of Ct and Hth in the antenna disc resulted in ectopic eye development in the antenna. PMID: 22912416
6. Data suggest that optimum levels of L and Hth are required to define the boundary between the developing eye and head cuticle on the ventral margin. PMID: 21920354
7. whole genome ChIP-chip studies to identify all of the Ubx bound regions in the haltere and T3 leg imaginal discs and the sites bound by the Hox cofactor PMID: 21483663
8. genome-wide analysis of the binding sites for the Hox cofactor Homothorax and the Hox protein Ultrabithorax PMID: 21483667
9. Regulation of ocellar specification and size by twin of eyeless and homothorax. PMID: 21104743
10. This work suggests that the transcriptional activity of all members of the Meis/Prep Hth protein family is subject to autoinhibition by their Hth domains, and that the Meis3.2 splice variant encodes a protein that bypasses this autoinhibitory effect. PMID: 20553494
11. experiments reveal three additional functions for hth: the cell cycle of progenitors is characterized by a relatively long G2 phase, which makes them prone to enter mitosis; hth represses the burst of string/cdc25 expression that precedes G1 arrest PMID: 20036228
12. homothorax specify antenna fates via regulation of multiple genes. PMID: 11934862
13. homothorax has a role in leg development in Drosophila PMID: 12385754
14. homothorax is both necessary and sufficient for inner Photoreceptors to adopt the polarization-sensitive DRA fate instead of the color-sensitive default state PMID: 14636555
15. Wingless andDecapentaplegic act independently as the primary signals for the repression of teashirt and hth, respectively PMID: 15509768
16. Alternative splicing of homothorax results in the generation of multiple transcription factors that execute unique functions in vivo. PMID: 16778079
17. analysis of control of splicing by alternative RNA secondary structures in Dipteran homothorax pre-mRNA PMID: 17114937
18. In the absence of homothorax gene activity, larval cells in Tr2 become non-proliferative and small imaginal cells are not produced, indicating that homothorax is necessary for proliferation of Tr2 larval cells. PMID: 18455715
19. Implication of Hth in the regulation of cell growth and endoreplication in larval salivary glands. PMID: 18481089
20. Homothorax transcription factor is maternally provided and that its function is necessary for the proper assembly of the centric/centromeric heterochromatin during preblastodermic divisions. PMID: 19652544

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KEGG: dme:Dmel_CG17117

STRING: 7227.FBpp0081732

UniGene: Dm.2272