Sincere Collaboration: A Review of CUSABIO's 2025 Annual Citations

A 76-year-old heavy smoker presented with progressive proximal weakness and respiratory failure; electrophysiology and anti-SOX1 antibodies confirmed Lambert–Eaton myasthenic syndrome, PET-CT revealed small-cell lung cancer, and combined oncologic and symptomatic therapy led to partial recovery, highlighting the need to screen for paraneoplastic neurologic syndromes.

Integrated WGS/RNA-seq of 203 ESCCs shows MUC mutations and APOBEC signatures predict poor outcome, whereas EpK pathway activation and high S100A8/A9 indicate favorable prognosis. A FU-ESCC three-subtype classifier stratifies patients—EpK, CAF-enriched, and immune-desert—guiding precision therapy.

A novel cyclic peptide Cp1, discovered via phage display, potently and stably neutralizes C5a, blocking the C5a-C5aR1 axis to curb inflammatory cascade, markedly reducing cytokines, organ damage and bacterial load in CLP septic mice, significantly prolonging survival after single dosing and offering a cost-effective sepsis intervention.

This study reveals that the mast cell receptor Mrgprb2, and its human ortholog MRGPRX2, orchestrate post-stroke brain inflammation by recruiting skull bone marrow neutrophils via the dura-brain axis, and inhibiting this receptor alleviates inflammation and improves outcomes.

Tumors hijack a nociceptive neuron-mediated inter-organ circuit: ATF4-SLIT2 activates sensory nerves, releasing CGRP to silence draining lymph nodes, damp CCL5, and skew TAMs to M2, fueling growth and blunting ICB. Disrupting this axis restores immunity, alleviates pain, and sensitizes tumors to checkpoint blockade.

Pg, a periodontal pathogen, degrades FOXO3 via LPS and gingipains, derepressing MSR1 to drive ox-LDL uptake and ROS production in macrophages, triggering necroptosis and expanding the necrotic core in atherosclerotic plaques. Antioxidants or MSR1 inhibition mitigate plaque instability.

This study shows that the FAK/SFK axis drives ESCC lymph node metastasis via tyrosine phosphorylation of metabolic enzymes ACLY and ALDOA, enhancing their activity and activating CDK7/9 or Yamanaka factors in primary vs. metastatic tumors. The natural compound quercetagitrin selectively inhibits ALDOA phosphorylation, suppressing metastasis and synergizing with FAK/SFK inhibitors, offering a promising anti-metastatic strategy.

This study reveals that γδ T-cell receptors (TCRs) can recognize intracellular proteins ectopically expressed on the cell membrane, such as nucleolin (NCL) and transglutaminase K (TGM1) under stress conditions, identifying a new pattern recognition mechanism. It also finds that radiation increases the expression of stress-induced proteins on tumor cells, enhancing the antitumor activity of γδ T cells and providing a novel strategy for tumor immunotherapy.

An MD-guided active-learning framework identified BMS-262084 as a nanomolar TMPRSS2 inhibitor with <20 experimental tests, potently blocking entry of SARS-CoV-2 variants and diverse coronaviruses.

This study maps human protein interactomes of ancestral and variant SARS-CoV-2 across organ-specific cells and saliva, revealing NSP3-induced coagulation defects via fibrinogen binding and immune evasion through IFIT5 de-ISGylation. Three antiviral peptides targeting the RBD were developed, effectively blocking ACE2 binding and inhibiting infection by both ancestral and variant strains, offering promising broad-spectrum antiviral candidates.

The study identifies hnRNPR mutations causing asthenoteratozoospermia by disrupting m6A-dependent splicing of SKAP2, impairing sperm cytoskeleton and mitochondria. SKAP2 delivery via milk extracellular vesicles restored sperm motility and morphology in both mice and humans, offering a novel therapeutic approach for male infertility.

This study genetically modeled ELP1-associated Sonic Hedgehog medulloblastoma (SHH-MB) and found that ELP1 heterozygous mutant mice exhibit genomic instability, mitotic defects, and differentiation stalling in granule neuron precursors (GNPs). Further experiments using orthotopic transplantation and patient-derived xenograft (PDX) models revealed dampened p53 signaling in ELP1-mutant tumors. Pharmacological inhibition of MDM2 significantly prolonged survival in ELP1-mutant SHH-MB mice, identifying MDM2 as a potential therapeutic target for ELP1-associated medulloblastoma.

R9AP is identified as a common receptor for EBV entry into both epithelial and B cells, binding the viral gH/gL complex to trigger membrane fusion. R9AP depletion, blocking peptides or monoclonal antibodies potently inhibit infection, highlighting its potential as a vaccine and antiviral target.

ATRX loss dismantles colonic epithelial identity via HNF4A inactivation, unlocking plastic mesenchymal and squamous-like states that fuel metastasis; human data confirm squamous signatures predict aggressive disease and poor outcome.

Using whole-cell phage display, we identified CD30L-targeting peptide TG-1 that disrupts CD30-CD30L signaling to suppress B-NHL proliferation; TG-1-conjugated gold nanoparticles co-delivering doxorubicin demonstrated potent and precise antitumor effects in vitro and in vivo.