Disintegrin and metalloproteinase domain-containing protein 17 is a protein in humans that is encoded by ADAM17 gene. Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.
The following ADAM17 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
ADAM17 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA001277GA01HU | ADAM17 Antibody |
Human,Mouse,Rat | ELISA,WB |
CSB-PA050198 | Cleaved-ADAM17 (R215) Antibody |
Human | WB, ELISA |
CSB-PA050199 | Phospho-ADAM17 (T735) Antibody |
Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA050200 | ADAM17 Antibody |
Human,Mouse,Rat | IF, ELISA |
CSB-PA261035 | ADAM17 Antibody |
Human,Mouse,Rat | ELISA,IHC |
CSB-RA797631A0HU | ADAM17 Recombinant Monoclonal Antibody |
Human | ELISA, IF |
ADAM17 Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-YP001277PI CSB-EP001277PI CSB-BP001277PI CSB-MP001277PI CSB-EP001277PI-B |
Recombinant Pig Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ADAM17 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-CF001277HU | Recombinant Human Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) |
in vitro E.coli expression system |
CSB-YP001277HU1 CSB-EP001277HU1 CSB-BP001277HU1 CSB-MP001277HU1 CSB-EP001277HU1-B |
Recombinant Human Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ADAM17 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E09315h | Human TNF α converting enzyme,TACE ELISA Kit |
serum, plasma, tissue homogenates, cell lysates | 15.6 pg/mL |
ADAM17 ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL001277MO | Mouse Disintegrin and metalloproteinase domain-containing protein 17(ADAM17) ELISA kit |
serum, plasma, tissue homogenates | 3.9 pg/mL |