BMX

BMX, also known as Bone marrow X kinase, is a member of the Tec family of non - receptor tyrosine kinases. It is commonly referred to as Etk. BMX functions through phosphorylation of specific substrates, thereby regulating cell growth, survival, and migration. It is involved in the PI3K - AKT signaling pathway, which is crucial for cell proliferation and anti - apoptosis.
Dysregulation of BMX has been linked to various diseases, including cancer and inflammatory disorders. In cancer, overexpression of BMX promotes tumor growth and metastasis. Currently, pharmaceutical companies are actively researching BMX - targeted therapies. Some small - molecule inhibitors are in pre - clinical and early - stage clinical trials, aiming to block its kinase activity and combat related diseases.