BRCA2

The BRCA2 gene encodes the breast cancer type 2 susceptibility protein, commonly known as BRCA2. It is a well - known tumor suppressor protein. BRCA2 mainly functions in DNA repair, particularly in homologous recombination. It interacts with RAD51 to promote proper alignment and repair of double - strand breaks, maintaining genomic stability. This protein is involved in the Fanconi anemia/BRCA pathway.
Mutations in BRCA2 are strongly associated with various cancers, especially breast and ovarian cancer. In the field of drug development, PARP inhibitors have shown significant efficacy in BRCA2 - mutated cancers. These drugs target the synthetic lethality between PARP and BRCA2, offering new treatment options for patients with BRCA2 - related malignancies.

Popular Product:

BRCA2 Antibody (CSB-PA553405)

Validated Data

The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA553405(BRCA2 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)

The following BRCA2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

BRCA2 Antibodies

BRCA2 Proteins

BRCA2 Antibodies

BRCA2 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA002796GA01HU	BRCA2 Antibody	Human	ELISA,WB
CSB-PA079435	Phospho-BRCA2 (Ser3291) Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA050157	Phospho-BRCA2 (S3291) Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA050158	BRCA2 Antibody	Human,Rat	IHC, ELISA
CSB-PA553405	BRCA2 Antibody	Human	ELISA,IHC

BRCA2 Antibodies for Drosophila simulans (Fruit fly)

Code	Product Name	Species Reactivity	Application
CSB-PA463556XA01DMJ	Brca2 Antibody	Drosophila simulans (Fruit fly)	ELISA, WB (ensure identification of antigen)

BRCA2 Antibodies for Drosophila sechellia (Fruit fly)

Code	Product Name	Species Reactivity	Application
CSB-PA465441XA01DMG	Brca2 Antibody	Drosophila sechellia (Fruit fly)	ELISA, WB (ensure identification of antigen)

BRCA2 Antibodies for Drosophila melanogaster (Fruit fly)

Code	Product Name	Species Reactivity	Application
CSB-PA894301XA01DLU	Brca2 Antibody	Drosophila melanogaster (Fruit fly)	ELISA, WB (ensure identification of antigen)

BRCA2 Proteins

BRCA2 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP002796HU CSB-EP002796HU CSB-BP002796HU CSB-MP002796HU CSB-EP002796HU-B	Recombinant Human Breast cancer type 2 susceptibility protein (BRCA2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

BRCA2 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP308755MO CSB-EP308755MO CSB-BP308755MO CSB-MP308755MO CSB-EP308755MO-B	Recombinant Mouse Breast cancer type 2 susceptibility protein homolog (Brca2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

BRCA2 Proteins for Drosophila simulans (Fruit fly)

Code	Product Name	Source
CSB-YP463556DMJ CSB-EP463556DMJ CSB-BP463556DMJ CSB-MP463556DMJ CSB-EP463556DMJ-B	Recombinant Drosophila simulans Breast cancer type 2 susceptibility protein homolog (Brca2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

BRCA2 Proteins for Drosophila sechellia (Fruit fly)

Code	Product Name	Source
CSB-YP465441DMG CSB-EP465441DMG CSB-BP465441DMG CSB-MP465441DMG CSB-EP465441DMG-B	Recombinant Drosophila sechellia Breast cancer type 2 susceptibility protein homolog (Brca2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

BRCA2 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP516591RA CSB-EP516591RA CSB-BP516591RA CSB-MP516591RA CSB-EP516591RA-B	Recombinant Rat Breast cancer type 2 susceptibility protein homolog (Brca2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

BRCA2 Proteins for Felis catus (Cat) (Felis silvestris catus)

Code	Product Name	Source
CSB-YP803032CA CSB-EP803032CA CSB-BP803032CA CSB-MP803032CA CSB-EP803032CA-B	Recombinant Cat Breast cancer type 2 susceptibility protein homolog (BRCA2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

BRCA2 Proteins for Drosophila melanogaster (Fruit fly)

Code	Product Name	Source
CSB-YP894301DLU CSB-EP894301DLU CSB-BP894301DLU CSB-MP894301DLU CSB-EP894301DLU-B	Recombinant Drosophila melanogaster Breast cancer type 2 susceptibility protein homolog (Brca2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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Popular Pathways

Apoptosis

Breast Cancer

Autophagy

Hippo Signaling Pathway

Wnt Signaling Pathway

Hippo signaling pathway

TGF-beta signaling pathway

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