The BTN2A2 protein, officially named Butyrophilin Subfamily 2 Member A2 and alternatively termed BTN2.2 or CD277 homolog, belongs to the B7-like immunomodulatory protein family. It regulates γδ T cell-mediated immune responses by interacting with BTN3A1 and phospholipid antigens, facilitating the activation of Vγ9Vδ2 T cells through indirect antigen presentation. This mechanism involves spatial reorganization of BTN3A1-BTN2A2 heteromers, enabling phosphoantigen sensing and subsequent T-cell receptor engagement. BTN2A2 intersects with the mevalonate pathway and co-stimulatory signaling networks, modulating inflammatory cytokine production and antitumor immunity. Dysregulation of BTN2A2 expression correlates with autoimmune disorders, infectious disease progression, and checkpoint blockade resistance in malignancies like melanoma.
Emerging evidence implicates BTN2A2 in cancer immunoediting and microbial defense, with altered expression observed in colorectal carcinoma and tuberculosis. Therapeutic strategies targeting BTN2A2 focus on enhancing γδ T cell cytotoxicity through bispecific antibodies or small-molecule BTN2A2-BTN3A1 complex stabilizers. Preclinical studies demonstrate that BTN2A2-targeted CAR-T cells exhibit improved tumor infiltration in epithelial cancers. A phase I trial (NCT05664243) is evaluating a BTN2A2/PD-1 dual-targeting monoclonal antibody for advanced solid tumors, while combinatorial approaches with zoledronate aim to amplify phosphoantigen-driven γδ T cell activation in hematologic malignancies.
Recombinant Human Butyrophilin subfamily 2 member A2 (BTN2A2), partial (CSB-EP848825HU)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
BTN2A2 Antibody (CSB-PA848825LA01HU)
Validated Data
Western blot
All lanes: BTN2A2 antibody at 10μg/ml
Lane 1: MCF-7 whole cell lysate
Lane 2: NIH/3T3 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 60, 38, 29, 46, 36 kDa
Observed band size: 60 kDa
Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA848825LA01HU at dilution of 1:100
The following BTN2A2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
BTN2A2 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA002871GA01HU | BTN2A2 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA848825LA01HU | BTN2A2 Antibody | Human, Mouse | ELISA, WB, IHC |
CSB-PA899996 | BTN2A2 Antibody | Human | ELISA,IHC |
CSB-PA114726 | BTN2A2 Antibody | Human | ELISA,IHC |
BTN2A2 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP848825HU | Recombinant Human Butyrophilin subfamily 2 member A2 (BTN2A2),Yeast, partial,Yeast | Yeast |
CSB-BP848825HU CSB-MP848825HU CSB-EP848825HU-B |
Recombinant Human Butyrophilin subfamily 2 member A2 (BTN2A2) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP848825HU | Recombinant Human Butyrophilin subfamily 2 member A2 (BTN2A2), partial | E.coli |