BUB3

Mitotic checkpoint protein BUB3is a protein in humans that is encoded by BUB3 gene. Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.

BUB3 Antibodies

BUB3 Antibodies for Homo sapiens (Human)

BUB3 Antibodies for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

BUB3 Antibodies for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

BUB3 Proteins

BUB3 Proteins for Homo sapiens (Human)

BUB3 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

BUB3 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

BUB3 Proteins for Bos taurus (Bovine)

BUB3 Proteins for Dictyostelium discoideum (Slime mold)

BUB3 Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

BUB3 Proteins for Mus musculus (Mouse)

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