CHMP2B Research Reagents

Charged multivesicular body protein 2b is a protein in humans that is encoded by CHMP2B gene. Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses).

The following CHMP2B reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

CHMP2B Antibodies

CHMP2B Antibodies for Homo sapiens (Human)

CHMP2B Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)

CHMP2B Proteins

CHMP2B Proteins for Bos taurus (Bovine)

CHMP2B Proteins for Gallus gallus (Chicken)

CHMP2B Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

CHMP2B Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

CHMP2B Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

CHMP2B Proteins for Mus musculus (Mouse)

CHMP2B Proteins for Homo sapiens (Human)

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