CLDN9

CLDN9, also known as claudin-9, is a transmembrane protein that forms tight junctions in various cell types. It plays a crucial role in maintaining cell polarity and paracellular permeability. CLDN9 is involved in the entry of hepatitis C virus and has been linked to tumor progression, including lung cancer and liver cancer. The protein's mechanism of action involves regulating tight junction permeability and modulating signaling pathways such as PI3K/AKT/HIF1α, which can suppress anti-tumor immunity. Research on CLDN9 inhibitors is ongoing, aiming to develop novel therapeutic strategies for cancer and other diseases.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CLDN9 at 2 μg/ml on an Nickel Coated plate can bind Anti-CLDN6/9 recombinant antibody (CSB-RA005508MA1HU). The EC₅₀ is 2.812-3.524 ng/mL.

The following CLDN9 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

CLDN9 Antibodies

CLDN9 Proteins

CLDN9 Antibodies

CLDN9 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA005511GA01HU	CLDN9 Antibody	Human,Mouse,Rat	ELISA,WB

CLDN9 Proteins

CLDN9 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-CF005511HU	Recombinant Human Claudin-9 (CLDN9)	in vitro E.coli expression system
CSB-YP005511HU1 CSB-EP005511HU1 CSB-BP005511HU1 CSB-MP005511HU1 CSB-EP005511HU1-B	Recombinant Human Claudin-9 (CLDN9), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-MP005511HU	Recombinant Human Claudin-9 (CLDN9)-VLPs (Active)	Mammalian cell
CSB-MP005511HU1-D	Recombinant Human Claudin-9 (CLDN9), partial-Detergent (Active)	Mammalian cell
CSB-MP005511HU-D	Recombinant Human Claudin-9 (CLDN9), partial-Detergent	Mammalian cell

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Popular Pathways

Apoptosis

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Autophagy

Hippo Signaling Pathway

Wnt Signaling Pathway

Hippo signaling pathway

TGF-beta signaling pathway

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CLDN9

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