CLEC7A

The gene CLEC7A encodes a protein known as C-type lectin domain containing 7A, also commonly referred to as DECTIN1. This protein functions as a pattern recognition receptor, specifically recognizing beta-1,3-linked and beta-1,6-linked glucans from fungi and plants. It plays a crucial role in innate immune response, particularly in the defense against fungal infections. CLEC7A is involved in various signaling pathways, including those related to TLR2-mediated inflammatory response and NF-kappa-B activation. Diseases associated with CLEC7A include aspergillosis, familial chronic mucocutaneous candidiasis, and possibly nasal polyps. Drug development efforts are ongoing, focusing on targeting CLEC7A for therapeutic applications, particularly in the context of immune disorders and fungal infections.