CRL5

CRL5, identified by other names such as CUL-5 and VACM-1, constitutes a multi-subunit protein complex. CRL5 comprises components like the structural protein Cullin 5, the RING protein SAG, the Elongin B/C adaptor protein, and the SOCS substrate recognition protein. It operates primarily through the orchestrated degradation of key regulatory proteins or by altering protein interaction mechanisms, thus implicating itself in various biological processes like cytokine signaling, inflammation, viral infection, and cancer development. As a prominent E3 ubiquitin ligase, CRL5 is critical for maintaining intracellular balance by meticulously controlling protein stability and activity, which significantly impacts both normal physiological functions and the progression of diseases.