CTNNA1

Catenin alpha-1 is a protein in humans that is encoded by CTNNA1 gene. Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.

CTNNA1 Antibodies

CTNNA1 Antibodies for Homo sapiens (Human)

CTNNA1 Proteins

CTNNA1 Proteins for Mus musculus (Mouse)

CTNNA1 Proteins for Homo sapiens (Human)

CTNNA1 Proteins for Bos taurus (Bovine)

CTNNA1 Proteins for Oryctolagus cuniculus (Rabbit)

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