Disheveled-associated activator of morphogenesis 2 is a protein that in humans is encoded by DDAM2 gene. Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity. During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A.
The following DAAM2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
DAAM2 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA774794ESR2HU | DAAM2 Antibody |
Human | ELISA, IHC |
CSB-PA774794LA01HU | DAAM2 Antibody |
Human | ELISA, IHC |
DAAM2 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP773901MO CSB-EP773901MO CSB-BP773901MO CSB-MP773901MO CSB-EP773901MO-B |
Recombinant Mouse Disheveled-associated activator of morphogenesis 2 (Daam2), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DAAM2 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP774794HU CSB-EP774794HU CSB-BP774794HU CSB-MP774794HU CSB-EP774794HU-B |
Recombinant Human Disheveled-associated activator of morphogenesis 2 (DAAM2), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |