Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities.
The following DIS3 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
DIS3 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA006911GA01HU | DIS3 Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA897532LA01HU | DIS3 Antibody |
Human | ELISA, IHC |
DIS3 Antibodies for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA263841XA01SVG | DIS3 Antibody |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | ELISA, WB (ensure identification of antigen) |
DIS3 Antibodies for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA334234XA01SXV | dis3 Antibody |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) | ELISA, WB (ensure identification of antigen) |
DIS3 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Code | Product Name | Source |
---|---|---|
CSB-YP334234SXV CSB-EP334234SXV CSB-BP334234SXV CSB-MP334234SXV CSB-EP334234SXV-B |
Recombinant Schizosaccharomyces pombe Exosome complex exonuclease dis3 (dis3), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DIS3 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP880423MO CSB-EP880423MO CSB-BP880423MO CSB-MP880423MO CSB-EP880423MO-B |
Recombinant Mouse Exosome complex exonuclease RRP44 (Dis3), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DIS3 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP897532HU CSB-EP897532HU CSB-BP897532HU CSB-MP897532HU CSB-EP897532HU-B |
Recombinant Human Exosome complex exonuclease RRP44 (DIS3), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |