DPH1

DPH1 （Diphthamide biosynthesis 1) is a DNA-binding protein that plays a role in the nucleus of cells and is of great significance for medical research and clinical applications. It is involved in regulating gene expression and affects its own activity and stability through phosphorylation modification, of which Ser235 and Ser238 are known phosphorylation modification sites. DPH1 is crucial for neural development, synaptic plasticity, and cognitive function. It catalyzes the modification of specific histidines in the elongation factor eEF2 to diphthamide, which is essential for the function of eEF2 in protein synthesis. DPH1 also participates in cell cycle regulation and tumor suppression, and its anti-tumor effect is related to the inhibition of DNA replication and cell proliferation of tumor cells. The abnormal expression of DPH1 is associated with various diseases including cancer, neurodegenerative diseases, and immune disorders, and its phosphorylation level is correlated with the intensity of its anti-tumor effect. Therefore, DPH1 is a potential target in drug development and therapeutic strategy research, and it is of great value for further understanding the occurrence and development mechanism of related diseases.