Endothelin Receptor Type A (EDNRA), also known as ET-A or ETAR, is a G protein-coupled receptor predominantly expressed in vascular smooth muscle cells. It binds endothelin-1 (ET-1) with high affinity, activating Gq/11 and Gα12/13 signaling pathways to mediate vasoconstriction, cell proliferation, and fibrosis. EDNRA is central to the endothelin signaling axis, interacting with pathways including PLC-IP3-Ca²⁺, MAPK/ERK, and RhoA/ROCK. Dysregulated EDNRA activity is implicated in pulmonary arterial hypertension (PAH), systemic hypertension, cancer progression (notably prostate and ovarian malignancies), and fibrotic disorders. Pharmacologically, EDNRA antagonists like ambrisentan and macitentan are FDA-approved for PAH, while investigational agents (e.g., zibotentan, clazosentan) target oncology and subarachnoid hemorrhage. Recent trials explore dual EDNRA/EDNRB inhibition to address pathway redundancy in resistant diseases. Structural studies continue to refine subtype-selective antagonist design to minimize off-target effects.
Recombinant Human Endothelin-1 receptor (EDNRA)-VLPs (Active) (CSB-MP007403HU)
Validated Data
CSB-MP007403HU is detected by Mouse anti-6*His monoclonal antibody.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human EDNRA at 10 μg/ml can bind Anti-EDNRA recombinant antibody(CSB-RA007403MA3HU). The EC50 is 2.225-3.570 ng/mL.The VLPs (CSB-MP3838) is negative control.
The purity of VLPs was greater than 95% as determined by SEC-HPLC
EDNRA (Getagozumab) Recombinant Monoclonal Antibody (CSB-RA007403MA3HU)
Validated Data
The Binding Activity of Human EDNRA with Anti-EDNRA Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human EDNRA(CSB-MP007403HU) at 10 μg/mL can bind Anti-EDNRA recombinant antibody. The EC50 is 2.225-3.570 ng/mL.
The VLPs (CSB-MP3838) is negative control.
The following EDNRA reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
EDNRA Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA002447 | EDNRA Antibody | Human,Mouse,Monkey | WB, IHC, IF, ELISA |
CSB-PA002449 | EDNRA Antibody | Human,Mouse,Rat | WB, IF, ELISA |
CSB-PA299262 | EDNRA Antibody | Human,Mouse | ELISA,WB,IHC |
EDNRA Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP007403HU1 | Recombinant Human Endothelin-1 receptor (EDNRA), partial | Yeast |
CSB-EP007403HU1 CSB-BP007403HU1 CSB-MP007403HU1 CSB-EP007403HU1-B |
Recombinant Human Endothelin-1 receptor (EDNRA), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF007403HU | Recombinant Human Endothelin-1 receptor (EDNRA) | in vitro E.coli expression system |
CSB-MP007403HU | Recombinant Human Endothelin-1 receptor (EDNRA)-VLPs (Active) | Mammalian cell |
EDNRA Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
Code | Product Name | Source |
---|---|---|
CSB-CF692301DO | Recombinant Dog Endothelin-1 receptor (EDNRA) | in vitro E.coli expression system |
CSB-YP692301DO1 CSB-EP692301DO1 CSB-BP692301DO1 CSB-MP692301DO1 CSB-EP692301DO1-B |
Recombinant Dog Endothelin-1 receptor (EDNRA), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EDNRA Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-CF007403RA | Recombinant Rat Endothelin-1 receptor (Ednra) | in vitro E.coli expression system |
CSB-YP007403RA1 CSB-EP007403RA1 CSB-BP007403RA1 CSB-MP007403RA1 CSB-EP007403RA1-B |
Recombinant Rat Endothelin-1 receptor (Ednra), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EDNRA Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-CF644898PI | Recombinant Pig Endothelin-1 receptor (EDNRA) | in vitro E.coli expression system |
CSB-YP644898PI1 CSB-EP644898PI1 CSB-BP644898PI1 CSB-MP644898PI1 CSB-EP644898PI1-B |
Recombinant Pig Endothelin-1 receptor (EDNRA), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EDNRA Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-CF737038MO | Recombinant Mouse Endothelin-1 receptor (Ednra) | in vitro E.coli expression system |
CSB-YP737038MO1 CSB-EP737038MO1 CSB-BP737038MO1 CSB-MP737038MO1 CSB-EP737038MO1-B |
Recombinant Mouse Endothelin-1 receptor (Ednra), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EDNRA Proteins for Ovis aries (Sheep)
Code | Product Name | Source |
---|---|---|
CSB-CF839205SH | Recombinant Sheep Endothelin-1 receptor (EDNRA) | in vitro E.coli expression system |
CSB-YP839205SH1 CSB-EP839205SH1 CSB-BP839205SH1 CSB-MP839205SH1 CSB-EP839205SH1-B |
Recombinant Sheep Endothelin-1 receptor (EDNRA), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EDNRA Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-CF007403BO | Recombinant Bovine Endothelin-1 receptor (EDNRA) | in vitro E.coli expression system |
CSB-YP007403BO1 CSB-EP007403BO1 CSB-BP007403BO1 CSB-MP007403BO1 CSB-EP007403BO1-B |
Recombinant Bovine Endothelin-1 receptor (EDNRA), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |