EIF3H

The protein EIF3H, also known as Eukaryotic Translation Initiation Factor 3 Subunit H, plays a crucial role in the initiation of protein synthesis. It is a component of the eukaryotic translation initiation factor 3 (eIF3) complex, which is essential for the assembly of the preinitiation complex. EIF3H stabilizes the interaction between the eIF3 complex and the small ribosomal subunit, thereby facilitating mRNA binding and translation initiation. This protein is involved in various signaling pathways, including those related to cell cycle progression and apoptosis. Aberrant expression of EIF3H has been associated with several diseases, such as Trichorhinophalangeal Syndrome, Type Ii and Prostate Cancer. In terms of drug development, targeting EIF3H is a potential therapeutic strategy for hepatocellular carcinoma, as it promotes tumor progression by stabilizing OGT and inhibiting ferroptosis.