Ephrin type-A receptor 4 (EPHA4), a member of the Eph receptor tyrosine kinase family, mediates cell-cell communication through binding to membrane-anchored ephrin ligands. Also known as HEK8 or TYRO1, it regulates bidirectional signaling pathways influencing cell adhesion, migration, and axon guidance during neurodevelopment. EPHA4 modulates Rho GTPase and MAPK/ERK cascades to orchestrate cytoskeletal dynamics and tissue patterning. Dysregulation of EPHA4 is implicated in amyotrophic lateral sclerosis (ALS), where reduced expression correlates with motor neuron degeneration, and in cancers such as glioblastoma through pro-invasive signaling. Preclinical studies highlight its dual role in spinal cord injury—promoting axonal regeneration yet inhibiting functional recovery via glial scar formation. While no EPHA4-targeted therapies are clinically approved, small-molecule inhibitors (e.g., dasatinib repurposing) and monoclonal antibodies are under investigation for neurological and oncological applications, though challenges persist in balancing its context-dependent pro-regenerative and pathological activities.
Recombinant Human Ephrin type-A receptor 4 (EPHA4), partial (Active) (CSB-AP005681HU)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
EPHA4 Antibody (CSB-PA007724LA01HU)
Validated Data
Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA007724LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA007724LA01HU at dilution of 1:100
Immunofluorescent analysis of Hela cells using CSB-PA007724LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Human Ephrin type-A receptor 4(EPHA4) ELISA kit (CSB-EL007724HU)
Validated Data
Code: CSB-EL007724HU
Size: 96T,5×96T,10×96T
Sensitivity: 6.25 pg/mL
Detection Range: 25 pg/mL-1600 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
The following EPHA4 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
EPHA4 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA959570 | Phospho-EPHA4 (Tyr596) Antibody | Human,Mouse | ELISA,WB |
CSB-PA008062 | Phospho-EPHA4 (Y596) Antibody | Human,Mouse | WB, ELISA |
CSB-PA830643 | EPHA4 Antibody | Human,Mouse | ELISA,IHC |
CSB-PA007724LA01HU | EPHA4 Antibody | Human | ELISA, IHC, IF |
CSB-PA007724LB01HU | EPHA4 Antibody, HRP conjugated | Human | ELISA |
CSB-PA007724LC01HU | EPHA4 Antibody, FITC conjugated | Human | |
CSB-PA007724LD01HU | EPHA4 Antibody, Biotin conjugated | Human | ELISA |
EPHA4 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP007724HU CSB-EP007724HU CSB-BP007724HU CSB-MP007724HU CSB-EP007724HU-B |
Recombinant Human Ephrin type-A receptor 4 (EPHA4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-AP005681HU | Recombinant Human Ephrin type-A receptor 4 (EPHA4), partial (Active) | Mammalian cell |
EPHA4 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL007724HU | Human Ephrin type-A receptor 4(EPHA4) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 6.25 pg/mL |