Epidermal growth factor receptor substrate 15 is a protein in humans that is encoded by EPS15 gene. Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
The following EPS15 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
EPS15 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA190074 | Phospho-EPS15 (Tyr849) Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA008076 | Phospho-EPS15 (Y849) Antibody | Human,Mouse,Rat | WB, ELISA |
EPS15 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP007748MO CSB-EP007748MO CSB-BP007748MO CSB-MP007748MO CSB-EP007748MO-B |
Recombinant Mouse Epidermal growth factor receptor substrate 15 (Eps15), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EPS15 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP007748HU CSB-BP007748HU CSB-MP007748HU CSB-EP007748HU-B |
Recombinant Human Epidermal growth factor receptor substrate 15 (EPS15), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EPS15 Proteins for Dictyostelium discoideum (Slime mold)
Code | Product Name | Source |
---|---|---|
CSB-YP687627DKK CSB-EP687627DKK CSB-BP687627DKK CSB-MP687627DKK CSB-EP687627DKK-B |
Recombinant Dictyostelium discoideum Epidermal growth factor receptor substrate 15 homolog (eps15), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |