Fc receptor-like protein 4 (FCRL4) contains 515 amino acids, including a signal peptide, 4 Ig-like domains, a transmembrane region of 16 amino acid sequences, and a cytoplasmic region of 106 amino acid sequences, of which there are 3 in cells. an ITIM-like motif. FCRL4, also commonly referred to as CD307d, is expressed in lymphocyte subsets in the spleen and lymph nodes, as well as in resting B cells. After FCRL4 is cross-linked with BCR, ITIM can bind to SHP-1 and SHP-2 and inhibit BCR-induced signal transduction, and only Tyr phosphorylation at sites 463 and 491 is sufficient; ITIM binds SHP-1 and SHP-2 It can inhibit the activity of Erk. This effect is weakened after mutation of 463 and 491 sites, and the effect is not affected after mutation of 453 site; 451, 463 tyrosine sites after ITIM phosphorylation in the intracellular region of FCRL4 can bind to phosphoric acid However, after phosphorylation of Tyr at 463, it can bind not only the phosphatases SHP-1 and SHP-2, but also the inositol phosphatase SHIP. ; After phosphorylation at sites 451 and 463 at the same time, it can bind to SHP-2 and lose the ability to bind SHP-1 and SHIP, but gain the ability to bind PLCy2; SHP-1 and SHP-2 can bind to phosphorylated 493, but the SH2 domain containing the Syk tyrosine kinase cannot bind any phosphorylated or unphosphorylated sites.
The following FCRL4 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
FCRL4 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA836277LC01HU | FCRL4 Antibody, FITC conjugated |
Human | |
CSB-PA836277LA01HU | FCRL4 Antibody |
Human | ELISA, WB |
CSB-PA836277LD01HU | FCRL4 Antibody, Biotin conjugated |
Human | ELISA |
FCRL4 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP836277HU | Recombinant Human Fc receptor-like protein 4 (FCRL4), partial |
Yeast |
CSB-EP836277HU | Recombinant Human Fc receptor-like protein 4 (FCRL4), partial |
E.coli |
CSB-MP836277HU | Recombinant Human Fc receptor-like protein 4 (FCRL4) |
Mammalian cell |
CSB-BP836277HU CSB-EP836277HU-B |
Recombinant Human Fc receptor-like protein 4 (FCRL4) |
Baculovirus In Vivo Biotinylation in E.coli |