FKBP1A

FKBP1A, FKBP prolyl isomerase 1A, alias FKBP12, is a protein with multiple biological functions in the cell, encoded by its own gene in human cells.The mechanism of action of FKBP1A involves its activity as a cis/trans peptidyl prolyl isomerase (PPIase). The mechanism of action of FKBP1A involves its activity as a cis/trans peptidyl prolyl isomerase (PPIase), which catalyzes the interconversion of cis and trans conformations of proline residues in the peptide chain of proteins, and thus participates in the regulation of protein folding and stability.FKBP1A is also involved in the regulation of various signaling pathways, including the mTOR/AKT signaling pathway.

FKBP1A is biologically significant in the regulation of a variety of cellular processes, including cell proliferation, metabolism, and cellular growth, as well as in the regulation of cellular physiology. including cell proliferation, metabolism, and immune response. In tumor biology, FKBP1A has been found to be up-regulated in a variety of cancers and correlated with the malignant behavior of tumors. For example, in gastric cancer, high expression of FKBP1A correlates with poor patient prognosis and may promote glucose metabolism and malignant biological behavior of cancer cells through activation of the PI3K/AKT signaling pathway. In addition, FKBP1A is involved in the regulation of inflammation-related signaling pathways and is important for processes such as inflammation, adaptive immune response, cancer and developmental biology.